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Coagulation factor XI (F11) Recombinant Protein | F11 recombinant protein

Recombinant Human Coagulation factor XI (F11)

Gene Names
F11; FXI
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Coagulation factor XI (F11); Recombinant Human Coagulation factor XI (F11); Coagulation factor XI; FXI; EC=3.4.21.27; Plasma thromboplastin antecedent; PTACleaved into the following 2 chains:; 1. Coagulation factor XIa heavy chain; 2. Coagulation factor XIa light chain; F11 recombinant protein
Ordering
For Research Use Only!
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
19-387. Partial
Sequence
ECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPR
Species
Homo sapiens (Human)
Production Note
Special Offer: The E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to [email protected] for more details.
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

SDS-Page

SDS-Page
Related Product Information for F11 recombinant protein
Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
Product Categories/Family for F11 recombinant protein

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
45.2 kDa
NCBI Official Full Name
coagulation factor XI
NCBI Official Synonym Full Names
coagulation factor XI
NCBI Official Symbol
F11
NCBI Official Synonym Symbols
FXI
NCBI Protein Information
coagulation factor XI; PTA; plasma thromboplastin antecedent
UniProt Protein Name
Coagulation factor XI
Protein Family
UniProt Gene Name
F11
UniProt Synonym Gene Names
FXI; PTA
UniProt Entry Name
FA11_HUMAN

NCBI Description

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]

Uniprot Description

F11: Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. Defects in F11 are the cause of factor XI deficiency (FA11D); also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate. Belongs to the peptidase S1 family. Plasma kallikrein subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; Secreted; Secreted, signal peptide; EC 3.4.21.27

Chromosomal Location of Human Ortholog: 4q35

Cellular Component: extracellular space; membrane; plasma membrane; extracellular region

Molecular Function: heparin binding; protein binding; serine-type endopeptidase activity

Biological Process: positive regulation of fibrinolysis; proteolysis; blood coagulation; blood coagulation, intrinsic pathway; plasminogen activation

Disease: Factor Xi Deficiency

Research Articles on F11

Similar Products

Product Notes

The F11 f11 (Catalog #AAA951109) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 19-387. Partial. The amino acid sequence is listed below: ECVTQLLKDT CFEGGDITTV FTPSAKYCQV VCTYHPRCLL FTFTAESPSE DPTRWFTCVL KDSVTETLPR VNRTAAISGY SFKQCSHQIS ACNKDIYVDL DMKGINYNSS VAKSAQECQE RCTDDVHCHF FTYATRQFPS LEHRNICLLK HTQTGTPTRI TKLDKVVSGF SLKSCALSNL ACIRDIFPNT VFADSNIDSV MAPDAFVCGR ICTHHPGCLF FTFFSQEWPK ESQRNLCLLK TSESGLPSTR IKKSKALSGF SLQSCRHSIP VFCHSSFYHD TDFLGEELDI VAAKSHEACQ KLCTNAVRCQ FFTYTPAQAS CNEGKGKCYL KLSSNGSPTK ILHGRGGISG YTLRLCKMDN ECTTKIKPR . It is sometimes possible for the material contained within the vial of "Coagulation factor XI (F11), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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