Rabbit anti-Human F11 Polyclonal Antibody | anti-F11 antibody

F11 (Coagulation Factor XI, FXI, Plasma Thromboplastin Antecedent, PTA, MGC141891) (PE)

Cat. Num. AAA6377843

• Gene Names: F11; FXI
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: F11; Polyclonal Antibody; F11 (Coagulation Factor XI; FXI; Plasma Thromboplastin Antecedent; PTA; MGC141891) (PE); anti-F11 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human F11.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-F11 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human F11, aa1-625 (NP_000119.1).
• Immunogen Sequence: MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQAV
• Conjugate: PE
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(F11 rabbit polyclonal antibody. Western Blot analysis of F11 expression in human liver.)

Western Blot (WB)

(Western Blot analysis of F11 expression in transfected 293T cell line by F11 polyclonal antibody. Lane 1: F11 transfected lysate (70.1kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-F11 antibody

Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.

Product Categories/Family for anti-F11 antibody

Antibodies; Coagulation Factors

NCBI and Uniprot Product Information

• NCBI GI #: 4503627
• NCBI GeneID: 2160
• NCBI Accession #: NP_000119.1
• NCBI GenBank Nucleotide #: NM_000128.2
• UniProt Accession #: P03951; Q4W5C2; Q9Y495; D3DP64
• Molecular Weight: 160,000
• NCBI Official Full Name: coagulation factor XI
• NCBI Official Synonym Full Names: coagulation factor XI
• NCBI Official Symbol: F11
• NCBI Official Synonym Symbols: FXI
• NCBI Protein Information: coagulation factor XI; PTA; plasma thromboplastin antecedent
• UniProt Protein Name: Coagulation factor XI
• Protein Family: Coagulation factor
• UniProt Gene Name: F11
• UniProt Synonym Gene Names: FXI; PTA
• UniProt Entry Name: FA11_HUMAN

NCBI Description

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]

Uniprot Description

F11: Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. Defects in F11 are the cause of factor XI deficiency (FA11D); also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate. Belongs to the peptidase S1 family. Plasma kallikrein subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; EC 3.4.21.27; Protease

Chromosomal Location of Human Ortholog: 4q35

Cellular Component: extracellular space; membrane; plasma membrane; extracellular region

Molecular Function: heparin binding; protein binding; serine-type endopeptidase activity

Biological Process: positive regulation of fibrinolysis; proteolysis; blood coagulation; blood coagulation, intrinsic pathway; plasminogen activation

Disease: Factor Xi Deficiency