Testing Data
(The TFact SRF DNA-Binding ELISA detects active SRF in Hela Nuclear Extract. The Hela cells were grown 3 days in DMEM with 10% FBS and harvested for nuclear extract. The Hela cells were stimulated by PMA (200nM) before harvest.)
Human, Mouse SRF ELISA Kit | SRF elisa kit
SRF TFact DNA-Binding ELISA Kit
Testing Data
(The TFact SRF DNA-Binding ELISA detects active SRF in Hela Nuclear Extract. The Hela cells were grown 3 days in DMEM with 10% FBS and harvested for nuclear extract. The Hela cells were stimulated by PMA (200nM) before harvest.)
Testing Data
(The TFact SRF DNA-Binding ELISA detects active SRF in Hela Nuclear Extract. The Hela cells were grown 3 days in DMEM with 10% FBS and harvested for nuclear extract. The Hela cells were stimulated by PMA (200nM) before harvest.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Uniprot Description
SRF: a transcription factor of the MADS domain family that binds to the serum response element (SRE). Regulates the transcription of immediate early genes including c-fos. Binds DNA as a multimer, probably a dimer.
Protein type: Motility/polarity/chemotaxis; Transcription factor
Chromosomal Location of Human Ortholog: 6p21.1
Cellular Component: cytoplasm; nuclear chromatin; nucleoplasm; nucleus
Molecular Function: chromatin DNA binding; DNA binding transcription factor activity; histone deacetylase binding; protein binding; protein homodimerization activity; serum response element binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; transcription factor binding
Biological Process: angiogenesis involved in wound healing; associative learning; branching involved in blood vessel morphogenesis; cardiac myofibril assembly; cell migration during sprouting angiogenesis; cell-matrix adhesion; cellular response to glucose stimulus; cellular senescence; developmental growth; epithelial cell-cell adhesion; epithelial structure maintenance; erythrocyte development; heart development; heart looping; hippocampus development; long-term memory; mesoderm formation; morphogenesis of an epithelial sheet; mRNA transcription from RNA polymerase II promoter; muscle maintenance; negative regulation of amyloid-beta clearance; negative regulation of cell migration; negative regulation of cell proliferation; neuron development; neuron migration; neuron projection development; platelet activation; platelet formation; positive regulation of axon extension; positive regulation of cell differentiation; positive regulation of filopodium formation; positive regulation of smooth muscle contraction; positive regulation of transcription by glucose; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation; positive regulation of transcription via serum response element binding; positive thymic T cell selection; primitive streak formation; regulation of cell adhesion; regulation of smooth muscle cell differentiation; regulation of water loss via skin; response to cytokine; response to hormone; response to hypoxia; response to toxin; sarcomere organization; skin morphogenesis; stress fiber assembly; tangential migration from the subventricular zone to the olfactory bulb; thymus development; thyroid gland development; transcription from RNA polymerase II promoter; trophectodermal cell differentiation
Research Articles on SRF
Similar Products
Product Notes
The Human, Mouse SRF srf (Catalog #AAA9502256) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9502256 ELISA Kit recognizes Human, Mouse SRF. It is sometimes possible for the material contained within the vial of "SRF, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
