Testing Data
(The TFact ETS1 DNA-Binding ELISA detects active ETS1 in Jurkat Nuclear Extract. The Jurkat cells were grown 3 days in RPMI 1640 with 10% FBS and harvested for nuclear extract. Jurkat cells were stimulated by PMA (200nM) before harvest. )
Human, Mouse ETS1 ELISA Kit | ETS1 elisa kit
ETS1 TFact DNA-Binding ELISA Kit
Testing Data
(The TFact ETS1 DNA-Binding ELISA detects active ETS1 in Jurkat Nuclear Extract. The Jurkat cells were grown 3 days in RPMI 1640 with 10% FBS and harvested for nuclear extract. Jurkat cells were stimulated by PMA (200nM) before harvest. )
Testing Data
(The TFact ETS1 DNA-Binding ELISA detects active ETS1 in Jurkat Nuclear Extract. The Jurkat cells were grown 3 days in RPMI 1640 with 10% FBS and harvested for nuclear extract. Jurkat cells were stimulated by PMA (200nM) before harvest. )
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Uniprot Description
Ets-1: a proto-oncogenic transcription factor homologous to the v-ets erythroblastosis virus oncogene. The DNA binding activity of Ets1 is controlled by kinases and transcription factors. It contributes to the regulation of cellular differentiation in hematopoietic cells. Ets1 promotes invasive behavior in endothelial cells, vascular smooth muscle cells and epithelial cancer cells. Regulates the expression of MMP1, MMP3, MMP9 and uPA as well as of VEGF and VEGFR gene expression. Two alternatively spliced isoforms have been described.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 11q24.3
Cellular Component: cytoplasm; nucleoplasm; nucleus; transcription factor complex
Molecular Function: DNA binding; DNA binding transcription factor activity; histone acetyltransferase binding; identical protein binding; protein binding; transcription factor binding
Biological Process: angiogenesis involved in wound healing; cell motility; cellular response to hydrogen peroxide; female pregnancy; hypothalamus development; immune response; negative regulation of cell proliferation; negative regulation of inflammatory response; pituitary gland development; PML body organization and biogenesis; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of cell proliferation; positive regulation of cellular component movement; positive regulation of endothelial cell migration; positive regulation of erythrocyte differentiation; positive regulation of gene expression; positive regulation of inflammatory response; positive regulation of leukocyte adhesion to vascular endothelial cell; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; regulation of angiogenesis; regulation of extracellular matrix disassembly; response to estradiol; response to hypoxia; response to laminar fluid shear stress; response to mechanical stimulus
Research Articles on ETS1
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Product Notes
The Human, Mouse ETS1 ets1 (Catalog #AAA9502161) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9502161 ELISA Kit recognizes Human, Mouse ETS1. It is sometimes possible for the material contained within the vial of "ETS1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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