Human, Mouse Abl ELISA Kit | Abl elisa kit
Phospho-Abl (Tyr412) Colorimetric Cell-Based ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
Uniprot Description
Arg: a cytoplasmic tyrosine kinase of the Abl family. Expressed at the highest levels in mature B cells. Promotes catalase degradation in the oxidative stress response. Localizes to dynamic actin structures and may regulate cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Abl family; EC 2.7.10.2; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Chromosomal Location of Human Ortholog: 1q25.2
Cellular Component: actin cytoskeleton; cytosol; extrinsic component of cytoplasmic side of plasma membrane
Molecular Function: actin filament binding; actin monomer binding; ATP binding; magnesium ion binding; manganese ion binding; non-membrane spanning protein tyrosine kinase activity; phosphotyrosine binding; protein binding; protein kinase activity; protein tyrosine kinase activity; receptor binding
Biological Process: cell adhesion; cellular protein modification process; cellular response to retinoic acid; elevation of cytosolic calcium ion concentration; innate immune response; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; positive regulation of neuron projection development; positive regulation of oxidoreductase activity; positive regulation of phospholipase C activity; regulation of actin cytoskeleton reorganization; regulation of autophagy; regulation of cell adhesion; regulation of cell motility; regulation of cell proliferation; regulation of endocytosis; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on Abl
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Product Notes
The Human, Mouse Abl abl2 (Catalog #AAA9501705) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501705 ELISA Kit recognizes Human, Mouse Abl. It is sometimes possible for the material contained within the vial of "Abl, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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