Western Blot (WB)
(Western Blot: Sample: Lane1: Mouse Brain Tissue; Lane2: Mouse Intestine Tissue; Lane3: Human Hela Cells; Lane4: Human 293T Cells.)
Rabbit anti-Mouse Optineurin Polyclonal Antibody | anti-OPTN antibody
Polyclonal Antibody to Optineurin (OPTN)
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Lane1: Mouse Brain Tissue; Lane2: Mouse Intestine Tissue; Lane3: Human Hela Cells; Lane4: Human 293T Cells.)
Western Blot (WB)
(Western Blot: Sample: Lane1: Mouse Brain Tissue; Lane2: Mouse Intestine Tissue; Lane3: Human Hela Cells; Lane4: Human 293T Cells.)
Western Blot (WB)
(Western Blot: Sample: Recombinant OPTN, Mouse.)
Western Blot (WB)
(Western Blot: Sample: Recombinant OPTN, Mouse.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Skeletal Muscle Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Skeletal Muscle Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Intestine Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Intestine Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Kidney Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Kidney Tissue.)
NCBI and Uniprot Product Information
Uniprot Description
optineurin: Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death. Defects in OPTN are the cause of primary open angle glaucoma type 1E (GLC1E). Primary open angle glaucoma (POAG) is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. Defects in OPTN are a cause of susceptibility to normal pressure glaucoma (NPG). Defects in OPTN are the cause of amyotrophic lateral sclerosis type 12 (ALS12). It is a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 2 A1|2 3.15 cM
Cellular Component: axon; cell soma; cytoplasm; cytoplasmic vesicle; cytosol; endosome; Golgi apparatus; nucleus; perinuclear region of cytoplasm; trans-Golgi network
Molecular Function: identical protein binding; metal ion binding; polyubiquitin modification-dependent protein binding; protein binding; protein binding, bridging; protein C-terminus binding; Rab GTPase binding; ubiquitin binding
Biological Process: autophagy; cellular protein localization; cellular response to unfolded protein; cytokine secretion; defense response to Gram-negative bacterium; Golgi organization and biogenesis; Golgi ribbon formation; Golgi to plasma membrane protein transport; immune system process; innate immune response; negative regulation of cell proliferation; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of neuron apoptosis; negative regulation of receptor recycling; parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization; positive regulation of autophagy; positive regulation of cell proliferation; positive regulation of cytokine production; positive regulation of gene expression; positive regulation of neural precursor cell proliferation; positive regulation of neuron apoptotic process; positive regulation of xenophagy; protein homooligomerization; protein targeting to Golgi; vesicle-mediated transport
Research Articles on OPTN
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Product Notes
The OPTN optn (Catalog #AAA2027726) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Optineurin (OPTN) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Optineurin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.5-2ug/mL Immunohistochemistry: 5-20ug/mL Immunocytochemistry: 5-20ug/mL Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the OPTN optn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Optineurin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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