Rabbit TLR4 Polyclonal Antibody | anti-Tlr4 antibody
TLR4 Antibody HRP Conjugated
Gene Names
Tlr4; Lps; Ly87; Ran/M1; Rasl2-8
Reactivity
Human, Mouse, Rat, Bovine
Applications
Western Blot, Immunohistochemistry
Purity
Purified by Protein A
Synonyms
TLR4; Polyclonal Antibody; TLR4 Antibody HRP Conjugated; Lps; Ly87; Ran M1; Rasl2-8; Toll-like receptor 4; CD284; Tlr4; anti-Tlr4 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat, Bovine
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Purified by Protein A
Form/Format
10mM Tris Buffered Saline containing 1% BSA, 50% glycerol and 0.09% Gentamicin.
Concentration
1mgml (varies by lot)
Applicable Applications for anti-Tlr4 antibody
Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P)
Application Notes
WB: 1:100-1000
IHC: 1:100-500
IHC: 1:100-500
Conjugation
HRP
Immunogen
KLH conjugated synthetic peptide aa 780-830 835 derived from rat TLR4
Preparation and Storage
Store at 4 degree C for 12 months.
Related Product Information for anti-Tlr4 antibody
Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.
Product Categories/Family for anti-Tlr4 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
95,519 Da
NCBI Official Full Name
toll-like receptor 4
NCBI Official Synonym Full Names
toll-like receptor 4
NCBI Official Symbol
Tlr4
NCBI Official Synonym Symbols
Lps; Ly87; Ran/M1; Rasl2-8
NCBI Protein Information
toll-like receptor 4; lipopolysaccharide response
UniProt Protein Name
Toll-like receptor 4
Protein Family
UniProt Gene Name
Tlr4
UniProt Synonym Gene Names
Lps
UniProt Entry Name
TLR4_MOUSE
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Product Notes
The Tlr4 tlr4 (Catalog #AAA9460194) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TLR4 Antibody HRP Conjugated reacts with Human, Mouse, Rat, Bovine and may cross-react with other species as described in the data sheet. AAA Biotech's TLR4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P). WB: 1:100-1000 IHC: 1:100-500. Researchers should empirically determine the suitability of the Tlr4 tlr4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TLR4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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