Rabbit PRR5 Polyclonal Antibody | anti-PRR5 antibody
PRR5 Polyclonal Antibody
PBS with 0.02% sodium azide, 50% glycerol, pH7.51
IHC: 1:50-1:200
IF: 1:50-1:200
NCBI and Uniprot Product Information
SDS PAGE MW: 53kDa
Uniprot Description
PROTOR1: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer. Belongs to the PROTOR family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Tumor suppressor
Chromosomal Location of Human Ortholog: 22q13
Cellular Component: TORC2 complex
Biological Process: positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid phosphorylation; cell cycle