Western Blot (WB)
(PPP2R1A Antibody (C-term) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the PPP2R1A antibody detected the PPP2R1A protein (arrow).)
Rabbit PPP2R1A Polyclonal Antibody | anti-PPP2R1A antibody
PPP2R1A Antibody (C-term)
Western Blot (WB)
(PPP2R1A Antibody (C-term) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the PPP2R1A antibody detected the PPP2R1A protein (arrow).)
Western Blot (WB)
(PPP2R1A Antibody (C-term) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the PPP2R1A antibody detected the PPP2R1A protein (arrow).)
phosphatase 2. Protein phosphatase 2 is one of the four major
Ser/Thr phosphatases, and it is implicated in the negative control
of cell growth and division. It consists of a common heteromeric
core enzyme, which is composed of a catalytic subunit and a
constant regulatory subunit, that associates with a variety of
regulatory subunits. The constant regulatory subunit A serves as a
scaffolding molecule to coordinate the assembly of the catalytic
subunit and a variable regulatory B subunit. This gene encodes an
alpha isoform of the constant regulatory subunit A. Alternatively
spliced transcript variants have been described. [provided by
RefSeq].
Schmitz, M.H., et al. Nat. Cell Biol. 12(9):886-893(2010)
Heikkinen, P.T., et al. J. Biol. Chem. 285(6):3740-3749(2010)
Dupont, W.D., et al. Cancer 116(1):8-19(2010)
Wang, Q., et al. Neoplasia 11(10):1012-1021(2009)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
Uniprot Description
PPP2R1A: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9. Interacts with TP53 and SGOL1. Interacts with PLA2G16; this interaction might decrease PP2A activity. Belongs to the phosphatase 2A regulatory subunit A family.
Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 19q13.41
Cellular Component: microtubule cytoskeleton; protein phosphatase type 2A complex; mitochondrion; membrane; nucleus; cytosol; chromosome, pericentric region
Molecular Function: protein binding; protein heterodimerization activity; protein phosphatase type 2A regulator activity; protein serine/threonine phosphatase activity; antigen binding
Biological Process: second-messenger-mediated signaling; regulation of cell adhesion; mitotic nuclear envelope reassembly; fibroblast growth factor receptor signaling pathway; apoptosis; RNA splicing; organelle organization and biogenesis; regulation of Wnt receptor signaling pathway; protein amino acid dephosphorylation; chromosome segregation; response to organic substance; regulation of transcription, DNA-dependent; regulation of cell differentiation; regulation of growth; mRNA catabolic process, nonsense-mediated decay; negative regulation of tyrosine phosphorylation of Stat3 protein; protein complex assembly; gene expression; mitotic cell cycle; negative regulation of cell growth; G2/M transition of mitotic cell cycle; ceramide metabolic process; regulation of DNA replication; inactivation of MAPK activity
Disease: Mental Retardation, Autosomal Dominant 36
Research Articles on PPP2R1A
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Product Notes
The PPP2R1A ppp2r1a (Catalog #AAA9213072) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 454-481. The PPP2R1A Antibody (C-term) reacts with Human (Predicted Reactivity: Bovine, Mouse, Pig) and may cross-react with other species as described in the data sheet. AAA Biotech's PPP2R1A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the PPP2R1A ppp2r1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PPP2R1A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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