Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using (HIRIP3 Antibody) at dilution 1/60.)
Rabbit anti-Human HIRIP3 Polyclonal Antibody | anti-HIRIP3 antibody
HIRIP3 Antibody
Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using (HIRIP3 Antibody) at dilution 1/60.)
Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using (HIRIP3 Antibody) at dilution 1/60.)
Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (HIRIP3 Antibody) at dilution 1/60.)
Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (HIRIP3 Antibody) at dilution 1/60.)
NCBI and Uniprot Product Information
NCBI Description
The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
Uniprot Description
DCPS: Necessary for the complete degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA fragments shorter than 10 nucleotides that are produced by 3'->5' exosome-mediated mRNA decay. Releases m7GMP. Can also degrade m7GDP to m7GMP. Has no activity towards mRNA molecules longer than 25 nucleotides. Belongs to the HIT family.
Protein type: EC 3.6.1.59; Hydrolase; RNA splicing
Chromosomal Location of Human Ortholog: 11q24.2
Cellular Component: nucleoplasm; mitochondrion; cytoplasm; cytosol; nucleus
Molecular Function: protein binding; m7G(5')pppN diphosphatase activity; RNA 7-methylguanosine cap binding
Biological Process: deadenylation-dependent decapping; negative regulation of programmed cell death; gene expression; nuclear mRNA cis splicing, via U2-type spliceosome; mRNA catabolic process, deadenylation-dependent decay
Disease: Al-raqad Syndrome
Research Articles on HIRIP3
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Product Notes
The HIRIP3 dcps (Catalog #AAA9434685) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HIRIP3 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's HIRIP3 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). IHC: 1:50-1:300. Researchers should empirically determine the suitability of the HIRIP3 dcps for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HIRIP3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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