Human Chondroitin sulfate proteoglycan 4 ELISA Kit | CSPG4 elisa kit
Human Chondroitin sulfate proteoglycan 4 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. [provided by RefSeq, Jul 2008]
Uniprot Description
NG2: a transmembrane chondrotin sulfate proteoglycan expressed on several types of immature progenitor cells and human malignant melanoma cells. Plays a role in cell proliferation and motility of endothelial cells during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. May regulate MPP16-dependent degradation and invasion of type I collagen participating to melanoma cells invasion properties. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through Cdc42, ACK1 and P130Cas. May activate FAK and ERK signaling cascades. PKC-alpha-mediated NG2 phosphorylation may be a key step for initiating cell polarization and motility.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 15q24.2
Cellular Component: cell surface; extracellular region; focal adhesion; Golgi lumen; integral to plasma membrane; lysosomal lumen
Molecular Function: protein kinase binding
Biological Process: chondroitin sulfate biosynthetic process; chondroitin sulfate catabolic process; dermatan sulfate biosynthetic process; glycosaminoglycan metabolic process; positive regulation of peptidyl-tyrosine phosphorylation
Research Articles on CSPG4
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Product Notes
The Human CSPG4 cspg4 (Catalog #AAA9428145) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9428145 ELISA Kit recognizes Human CSPG4. It is sometimes possible for the material contained within the vial of "Chondroitin sulfate proteoglycan 4, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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