Human Microtubule-associated protein tau ELISA Kit | MAPT elisa kit
Human Microtubule-associated protein tau ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
Uniprot Description
Tau: a microtubule-associated protein that regulates microtubule assembly and stability. Apparently involved in the establishment and maintenance of neuronal polarity. Mutations can result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. Nine differentially spliced isoforms have been described. The short isoforms allow plasticity of the cytoskeleton, whereas the longer isoforms may preferentially play a role in its stabilization.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 17q21.31
Cellular Component: axolemma; axon; cell soma; cytoplasm; cytosol; dendrite; growth cone; membrane; microtubule associated complex; microtubule cytoskeleton; nuclear speck; nucleus; plasma membrane; tubulin complex
Molecular Function: actin binding; apolipoprotein binding; DNA binding; enzyme binding; Hsp90 protein binding; identical protein binding; microtubule binding; protein binding; protein homodimerization activity; protein phosphatase 2A binding; receptor agonist activity; SH3 domain binding
Biological Process: astrocyte activation; axon transport of mitochondrion; caspase activation; cytoplasmic microtubule organization and biogenesis; intracellular distribution of mitochondria; memory; microglial cell activation; microtubule cytoskeleton organization and biogenesis; negative regulation of kinase activity; neurite development; positive regulation of axon extension; positive regulation of microtubule polymerization; positive regulation of superoxide release; protein oligomerization; regulation of autophagy; regulation of calcium-mediated signaling; regulation of microtubule polymerization or depolymerization; synapse organization and biogenesis
Disease: Frontotemporal Dementia; Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-related; Parkinson Disease, Late-onset; Parkinson-dementia Syndrome; Pick Disease Of Brain; Supranuclear Palsy, Progressive, 1
Research Articles on MAPT
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Product Notes
The Human MAPT mapt (Catalog #AAA9427981) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9427981 ELISA Kit recognizes Human MAPT. It is sometimes possible for the material contained within the vial of "Microtubule-associated protein tau, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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