C-C motif chemokine 4 (Ccl4) Recombinant Protein | Ccl4 recombinant protein
Recombinant Mouse C-C motif chemokine 4 protein (Ccl4)
NCBI and Uniprot Product Information
Uniprot Description
CCL4: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. Belongs to the intercrine beta (chemokine CC) family.
Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11 C|11 51.09 cM
Cellular Component: extracellular space
Molecular Function: CCR chemokine receptor binding; CCR1 chemokine receptor binding; CCR5 chemokine receptor binding; chemokine activity; identical protein binding; protein binding
Biological Process: G-protein coupled receptor protein signaling pathway; inflammatory response; leukocyte chemotaxis; lymphocyte chemotaxis; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of calcium ion transport; positive regulation of calcium-mediated signaling; positive regulation of GTPase activity; positive regulation of tumor necrosis factor production; positive regulation of vascular permeability; response to toxin
Research Articles on Ccl4
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Product Notes
The Ccl4 ccl4 (Catalog #AAA9422924) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Recombinant Mouse C-C motif chemokine 4 protein (Ccl4) reacts with Mouse and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "C-C motif chemokine 4 (Ccl4), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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