Eukaryotic translation initiation factor 5 Recombinant Protein | IF5 recombinant protein

Recombinant Human Eukaryotic translation initiation factor 5

Cat. Num. AAA9420207

• Gene Names: EIF5; EIF-5; EIF-5A
• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Eukaryotic translation initiation factor 5; Recombinant Human Eukaryotic translation initiation factor 5; IF5 recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Full Length, 1-431aa

• Tag Info: His-SUMO-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for IF5 recombinant protein

Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).

NCBI and Uniprot Product Information

• NCBI GI #: 21361337
• NCBI GeneID: 1983
• NCBI Accession #: NP_001960.2
• NCBI GenBank Nucleotide #: NM_001969.4
• UniProt Accession #: P55010; Q53XB3; Q9H5N2; Q9UG48
• Molecular Weight: 65.2kD
• NCBI Official Full Name: eukaryotic translation initiation factor 5
• NCBI Official Synonym Full Names: eukaryotic translation initiation factor 5
• NCBI Official Symbol: EIF5
• NCBI Official Synonym Symbols: EIF-5; EIF-5A
• NCBI Protein Information: eukaryotic translation initiation factor 5
• UniProt Protein Name: Eukaryotic translation initiation factor 5
• Protein Family: Eukaryotic translation initiation factor
• UniProt Gene Name: EIF5
• UniProt Synonym Gene Names: eIF-5

NCBI Description

Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting functional 80S ribosomal initiation complex is then active in peptidyl transfer and chain elongations (summary by Si et al., 1996 [PubMed 8663286]).[supplied by OMIM, May 2010]

Uniprot Description

EIF5: eukaryotic translation initiation factor 5. Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex.

Protein type: Translation; Translation initiation

Chromosomal Location of Human Ortholog: 14q32.32

Cellular Component: cytoplasm; cytosol; nucleus; plasma membrane

Molecular Function: cadherin binding; GTPase activity; protein binding; RNA binding; translation factor activity, nucleic acid binding

Biological Process: regulation of translational initiation