Eukaryotic translation initiation factor 3 subunit G Recombinant Protein | EIF3G recombinant protein

Recombinant Human Eukaryotic translation initiation factor 3 subunit G

Cat. Num. AAA9420203

• Gene Names: EIF3G; EIF3S4; EIF3-P42; eIF3-p44; eIF3-delta
• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Eukaryotic translation initiation factor 3 subunit G; Recombinant Human Eukaryotic translation initiation factor 3 subunit G; Eukaryotic translation initiation factor 3; EIF3G recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Full Length, 2-320aa

• Tag Info: His-SUMO-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for EIF3G recombinant protein

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassbly and recycling of post-termination ribosomal complexes and subsequently prevents prature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit can bind 18S rRNA.

NCBI and Uniprot Product Information

• NCBI GI #: 49472822
• NCBI GeneID: 8666
• NCBI Accession #: NP_003746.2
• NCBI GenBank Nucleotide #: NM_003755.4
• UniProt Accession #: O75821; O14801; Q969U5
• Molecular Weight: 51.46kD
• NCBI Official Full Name: eukaryotic translation initiation factor 3 subunit G
• NCBI Official Synonym Full Names: eukaryotic translation initiation factor 3 subunit G
• NCBI Official Symbol: EIF3G
• NCBI Official Synonym Symbols: EIF3S4; EIF3-P42; eIF3-p44; eIF3-delta
• NCBI Protein Information: eukaryotic translation initiation factor 3 subunit G
• UniProt Protein Name: Eukaryotic translation initiation factor 3 subunit G
• Protein Family: Eukaryotic translation initiation factor
• UniProt Gene Name: EIF3G
• UniProt Synonym Gene Names: eIF3g; eIF-3 RNA-binding subunit

NCBI Description

This gene encodes a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is required for initiation of protein translation. An N-terminal caspase cleavage product of the encoded protein may stimulate degradation of DNA. A mutation in this gene is associated with narcolepsy. [provided by RefSeq, Jul 2016]

Uniprot Description

eIF3-delta: eukaryotic translation initiation factor 3 subunit 4. Binds to the 40S ribosome and promotes the binding of methionyl-tRNAi and mRNA. This subunit binds to the 18S rRNA. eIF-3 is composed of at least 12 different subunits. Contains 1 RNA recognition motif (RRM) domain.

Protein type: RNA-binding; Translation; Translation initiation

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: cytoplasm; cytosol; eukaryotic translation initiation factor 3 complex; nucleus

Molecular Function: protein binding; RNA binding; translation initiation factor activity

Biological Process: translational initiation