Rabbit anti-Human NALP10 Polyclonal Antibody | anti-NALP10 antibody

NALP10 Antibody

Cat. Num. AAA9413232

• Gene Names: NLRP10; NOD8; PAN5; PYNOD; NALP10; CLR11.1
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: NALP10; Polyclonal Antibody; NALP10 Antibody; NACHT; LRR and PYD domains-containing protein 10; NLRP10; NOD8; CLR11.1; PAN5; PYNOD; anti-NALP10 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 655

• Applicable Applications for anti-NALP10 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 14 amino acid peptide near the amino terminus of human NALP10.
• Target Name: NALP10
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of NALP10 in human brain tissue lysate with NALP10 antibody at 1 ug/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of NALP10 in human brain tissue with NALP10 antibody at 10 ug/mL.)

Related Product Information for anti-NALP10 antibody

NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP10 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It was initially identified as PYNOD, an Apaf-1-like protein that binds to ASC, caspase-1 and IL-1b, inhibiting the autoprocessing of caspase-1, caspase-1-mediated IL-1b processing, and ASC aggregation. NALP10 is thus a potent regulator of apoptosis and inflammation.

Product Categories/Family for anti-NALP10 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 28827807
• NCBI GeneID: 338322
• NCBI Accession #: NP_789791
• NCBI GenBank Nucleotide #: NM_176821.3
• Molecular Weight: 75,032 Da
• NCBI Official Full Name: NACHT, LRR and PYD domains-containing protein 10
• NCBI Official Synonym Full Names: NLR family, pyrin domain containing 10
• NCBI Official Symbol: NLRP10
• NCBI Official Synonym Symbols: NOD8; PAN5; PYNOD; NALP10; CLR11.1
• NCBI Protein Information: NACHT, LRR and PYD domains-containing protein 10
• UniProt Protein Name: NACHT, LRR and PYD domains-containing protein 10
• UniProt Gene Name: NLRP10
• UniProt Synonym Gene Names: NALP10; NOD8; PYNOD
• UniProt Entry Name: NAL10_HUMAN

NCBI Description

Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008]

Uniprot Description

NALP10: Inhibits CASP1/caspase-1-dependent IL1B secretion and PYCARD-mediated apoptosis, but not that induced by FAS or BID. Belongs to the NLRP family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 11p15.4

Cellular Component: extrinsic to plasma membrane; cytoplasm

Molecular Function: ATP binding

Biological Process: positive regulation of T-helper 1 type immune response; innate immune response; defense response to Gram-negative bacterium; defense response to fungus