Rabbit DAB2IP Polyclonal Antibody | anti-DAB2IP antibody

DAB2IP Antibody

Cat. Num. AAA9411254

• Gene Names: DAB2IP; AIP1; AIP-1; AF9Q34; DIP1/2
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: DAB2IP; Polyclonal Antibody; DAB2IP Antibody; AIP1; AIP-1; AF9Q34; DIP1/2; anti-DAB2IP antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total DAB2IP protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 2.8 mg/ml (varies by lot)
• Sequence Length: 1132

• Applicable Applications for anti-DAB2IP antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:50-1:200
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to residues near the C terminal of human DAB2 interacting protein
• Target Name: DAB2IP
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using at dilution 1/40.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/40.)

Related Product Information for anti-DAB2IP antibody

DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers

Product Categories/Family for anti-DAB2IP antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 94967023
• NCBI GeneID: 153090
• NCBI Accession #: NP_115941.2
• NCBI GenBank Nucleotide #: NM_032552.3
• UniProt Accession #: Q5VWQ8; Q8TDL2; Q96SE1; Q9C0C0; A6H8V2; A6NHI9; B0QZB1; G3XA90
• Molecular Weight: 125,041 Da
• NCBI Official Full Name: disabled homolog 2-interacting protein isoform 1
• NCBI Official Synonym Full Names: DAB2 interacting protein
• NCBI Official Symbol: DAB2IP
• NCBI Official Synonym Symbols: AIP1; AIP-1; AF9Q34; DIP1/2
• NCBI Protein Information: disabled homolog 2-interacting protein
• UniProt Protein Name: Disabled homolog 2-interacting protein
• Protein Family: Disabled homolog 2-interacting protein
• UniProt Gene Name: DAB2IP
• UniProt Synonym Gene Names: AF9Q34; AIP1; KIAA1743; DAB2 interaction protein; DAB2-interacting protein; AIP-1
• UniProt Entry Name: DAB2P_HUMAN

NCBI Description

DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).[supplied by OMIM, May 2010]

Uniprot Description

DAB2IP: Functions as a Ras GTPase-activating protein. Through its interaction with MAP3K5 disrupts the association of MAP3K5 with the inhibitory 14-3-3 complex. Mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK- NF-kappa-B signaling. May act as a tumor suppressor gene. A chromosomal aberration involving DAB2IP is found in a patient with acute myeloid leukemia (AML). Translocation t(9;11)(q34;q23) with MLL. May give rise to a MLL-DAB2IP fusion protein lacking the PH domain. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs, Ras; GAPs; Tumor suppressor

Chromosomal Location of Human Ortholog: 9q33.1-q33.3

Cellular Component: cell soma; axon; endocytic vesicle; cytoplasm; dendrite; plasma membrane

Molecular Function: identical protein binding; protein homodimerization activity; protein phosphatase 2A binding; mitogen-activated protein kinase kinase binding; death receptor binding; mitogen-activated protein kinase kinase kinase binding; protein kinase binding; protein binding; vascular endothelial growth factor receptor 2 binding; protein complex binding; phosphoinositide 3-kinase binding; SH3 domain binding; kinase binding; phosphatidylinositol 3-phosphate binding

Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; positive regulation of JNK activity; negative regulation of MAP kinase activity; regulation of protein heterodimerization activity; positive regulation of apoptosis; positive regulation of JNK cascade; negative regulation of transcription from RNA polymerase II promoter; activation of JNK activity; negative regulation of cell proliferation; negative regulation of phosphoinositide 3-kinase activity; positive regulation of MAPKKK cascade; negative regulation of protein amino acid phosphorylation; regulation of growth; regulation of protein complex assembly; negative regulation of Ras protein signal transduction; angiogenesis; inflammatory response; regulation of I-kappaB kinase/NF-kappaB cascade; layer formation in the cerebral cortex; negative regulation of epithelial cell proliferation; transformed cell apoptosis; negative regulation of vascular endothelial growth factor receptor signaling pathway; lumen formation; negative regulation of I-kappaB kinase/NF-kappaB cascade; cell cycle; negative regulation of angiogenesis; unfolded protein response, activation of signaling protein activity; induction of apoptosis via death domain receptors; cellular protein catabolic process; inhibition of NF-kappaB transcription factor; negative regulation of fibroblast proliferation; negative regulation of toll-like receptor 4 signaling pathway; activation of MAPKKK activity; positive regulation of protein catabolic process; innate immune response; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; I-kappaB phosphorylation; cell locomotion involved in cerebral cortex radial glia guided migration; neurite morphogenesis; negative regulation of phosphoinositide 3-kinase cascade