Rabbit LYRM1 Polyclonal Antibody | anti-LYRM1 antibody

LYRM1 Antibody

Cat. Num. AAA9410910

• Gene Names: LYRM1; A211C6.1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: LYRM1; Polyclonal Antibody; LYRM1 Antibody; LYR motif-containing protein 1; anti-LYRM1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 248

• Applicable Applications for anti-LYRM1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 17 amino acid peptide near the center of human LYRM1.
• Target Name: LYRM1
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of LYRM1 in human liver tissue lysate with LYRM1 antibody at (A) 1 and (B) 2 ug/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of LYRM1 in rat liver tissue with LYRM1 antibody at 5 ug/mL.)

Related Product Information for anti-LYRM1 antibody

LYRM1 was one of many genes identified through a suppression subtractive hybridization comparing their expression in omental adipose tissue of obese patients compared to non-obese individuals. Further study confirms that both mRNA and protein levels of LYRM1 are higher in obese individuals. LYRM1 is widely expressed, with highest levels occurring in adipose and liver tissues. It is thought that LYRM1 promotes preadipocyte proliferation and can inhibit apoptosis of preadipocytes. Ectopic LYRM1 expression did not significantly affect adipogenesis, suggesting that LYRM1 can influence adipose tissue homeostasis by modulating the size of the preadipocyte pool.

Product Categories/Family for anti-LYRM1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 119587248
• NCBI GeneID: 57149
• Molecular Weight: 14,282 Da
• NCBI Official Full Name: hypothetical protein A-211C6.1, isoform CRA_b
• NCBI Official Synonym Full Names: LYR motif containing 1
• NCBI Official Symbol: LYRM1
• NCBI Official Synonym Symbols: A211C6.1
• NCBI Protein Information: LYR motif-containing protein 1
• UniProt Protein Name: LYR motif-containing protein 1
• Protein Family: LYR motif containing protein
• UniProt Gene Name: LYRM1
• UniProt Entry Name: LYRM1_HUMAN

NCBI Description

The protein encoded by this gene belongs to the mitochondrial leucine/tyrosine/arginine motif family of proteins. Proteins of this family are short polypeptides that contain a leucine/tyrosine/arginine motif near the N-terminus. This gene is widely expressed with high levels in omental adipose tissue of obese individuals. In adipose tissue, the protein is localized to the nucleus where it promotes preadipocyte proliferation and lowers the rate of apoptosis to regulate adipose tissue homeostasis. Overexpression of this gene in adipocytes causes abnormal mitochondrial morphology and mitochondrial dysfunction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Uniprot Description

LYRM1: May promote cell proliferation and inhibition of apoptosis of preadipocytes. When overexpressed, may be involved in obesity- associated insulin resistance, possibly by causing mitochondrial dysfunction in adipocytes. Belongs to the complex I LYR family.

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: nucleoplasm; intercellular bridge; mitochondrion