Loading...

Skip to main content

Call us on + 1 (800) 604-9114 for more information about our products

Looking for specific datasheet Manual/COA/MSDS?
Request a Manual/COA/MSDS

Interested to get a quote about our products?
Request a Quote

Testing Data (Gel: 10%SDS-PAGE Lysates (from left to right): Human fetal liver tissue and mouse heart tissue,human testis tissue Amount of lysate: 40ug per lane Primary antibody: 1/475 dilution Secondary antibody dilution: 1/8000 Exposure time: 1 minute)

Rabbit anti-Human, Mouse IRAK1BP1 Polyclonal Antibody | anti-IRAK1BP1 antibody

IRAK1BP1 Antibody

Gene Names
IRAK1BP1; AIP70; SIMPL
Reactivity
Human, Mouse
Applications
Western Blot, Immunohistochemistry
Purity
Antigen affinity purification.
Synonyms
IRAK1BP1; Polyclonal Antibody; IRAK1BP1 Antibody; AIP70; SIMPL; anti-IRAK1BP1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Specificity
The antibody detects endogenous levels of total IRAK1BP1 protein.
Purity/Purification
Antigen affinity purification.
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Concentration
1.9 mg/ml (varies by lot)
Sequence Length
260
Applicable Applications for anti-IRAK1BP1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
Western blotting: 1:500-1:2000
Immunohistochemistry: 1:50-1:200
Immunogen Type
Recombinant Protein
Immunogen Description
Full length fusion protein
Target Name
IRAK1BP1
Preparation and Storage
Store at -20 degree C

Testing Data

(Gel: 10%SDS-PAGE Lysates (from left to right): Human fetal liver tissue and mouse heart tissue,human testis tissue Amount of lysate: 40ug per lane Primary antibody: 1/475 dilution Secondary antibody dilution: 1/8000 Exposure time: 1 minute)

Testing Data (Gel: 10%SDS-PAGE Lysates (from left to right): Human fetal liver tissue and mouse heart tissue,human testis tissue Amount of lysate: 40ug per lane Primary antibody: 1/475 dilution Secondary antibody dilution: 1/8000 Exposure time: 1 minute)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using at dilution 1/40.)

Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using at dilution 1/40.)
Related Product Information for anti-IRAK1BP1 antibody
SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-alpha induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fully active.
Product Categories/Family for anti-IRAK1BP1 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
29,106 Da
NCBI Official Full Name
interleukin-1 receptor-associated kinase 1-binding protein 1
NCBI Official Synonym Full Names
interleukin-1 receptor-associated kinase 1 binding protein 1
NCBI Official Symbol
IRAK1BP1
NCBI Official Synonym Symbols
AIP70; SIMPL
NCBI Protein Information
interleukin-1 receptor-associated kinase 1-binding protein 1
UniProt Protein Name
Interleukin-1 receptor-associated kinase 1-binding protein 1
UniProt Gene Name
IRAK1BP1
UniProt Synonym Gene Names
IRAK1-binding protein 1
UniProt Entry Name
IKBP1_HUMAN

Uniprot Description

IRAK1BP1: Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity. Belongs to the IRAK1BP1 family.

Protein type: Transcription regulation

Chromosomal Location of Human Ortholog: 6q14-q15

Cellular Component: cytoplasm; nucleus

Biological Process: I-kappaB kinase/NF-kappaB cascade; regulation of transcription, DNA-dependent; transcription, DNA-dependent; immune response

Research Articles on IRAK1BP1

Similar Products

Product Notes

The IRAK1BP1 irak1bp1 (Catalog #AAA9410809) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IRAK1BP1 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's IRAK1BP1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western blotting: 1:500-1:2000 Immunohistochemistry: 1:50-1:200. Researchers should empirically determine the suitability of the IRAK1BP1 irak1bp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IRAK1BP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

Item has been added to Shopping Cart

If you are ready to order, navigate to Shopping Cart and get ready to checkout.

Looking for a specific manual?
Request a Manual

Request more Information

Please complete the form below and a representative will contact you as soon as possible.

Request a Manual

Please complete the form below and a representative will contact you as soon as possible.

Request a Quote

Please complete the form below and a representative will contact you as soon as possible.