Testing Data
(Gel: 8%SDS-PAGE Lysates (from left to right): Mouse liver tissue and Raji cell, hela, hepG2 and A549 cell Amount of lysate: 40ug per lane Primary antibody: 1/266.6 dilution Secondary antibody dilution: 1/8000 Exposure time: 20 seconds)
Rabbit anti-Human, Mouse CAT Polyclonal Antibody | anti-CAT antibody
CAT Antibody
Immunohistochemistry: 1:50-1:200
Testing Data
(Gel: 8%SDS-PAGE Lysates (from left to right): Mouse liver tissue and Raji cell, hela, hepG2 and A549 cell Amount of lysate: 40ug per lane Primary antibody: 1/266.6 dilution Secondary antibody dilution: 1/8000 Exposure time: 20 seconds)
Testing Data
(Gel: 8%SDS-PAGE Lysates (from left to right): Mouse liver tissue and Raji cell, hela, hepG2 and A549 cell Amount of lysate: 40ug per lane Primary antibody: 1/266.6 dilution Secondary antibody dilution: 1/8000 Exposure time: 20 seconds)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/40.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/40.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]
Uniprot Description
Catalase: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells. Homotetramer. Belongs to the catalase family.
Protein type: EC 1.11.1.6; Endoplasmic reticulum; Hydrolase; Apoptosis; Mitochondrial; Amino Acid Metabolism - tryptophan; Energy Metabolism - methane; Oxidoreductase
Chromosomal Location of Human Ortholog: 11p13
Cellular Component: Golgi apparatus; peroxisomal membrane; peroxisomal matrix; focal adhesion; intracellular membrane-bound organelle; membrane; lysosome; endoplasmic reticulum; plasma membrane; mitochondrial intermembrane space; peroxisome; cytosol
Molecular Function: antioxidant activity; oxidoreductase activity, acting on peroxide as acceptor; enzyme binding; protein homodimerization activity; catalase activity; metal ion binding; heme binding; NADP binding; aminoacylase activity; receptor binding
Biological Process: cholesterol metabolic process; nucleobase, nucleoside and nucleotide metabolic process; hemoglobin metabolic process; purine base metabolic process; activation of NF-kappaB transcription factor; protein homotetramerization; osteoblast differentiation; positive regulation of phosphoinositide 3-kinase cascade; response to vitamin E; response to reactive oxygen species; response to hyperoxia; triacylglycerol metabolic process; UV protection; hydrogen peroxide catabolic process; inhibition of NF-kappaB transcription factor; ureteric bud development; positive regulation of cell division; response to hypoxia; aerobic respiration; purine nucleotide catabolic process; protein tetramerization; aging; negative regulation of apoptosis
Disease: Acatalasemia
Research Articles on CAT
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Product Notes
The CAT cat (Catalog #AAA9409315) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CAT Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CAT can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western blotting: 1:500-1:2000 Immunohistochemistry: 1:50-1:200. Researchers should empirically determine the suitability of the CAT cat for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CAT, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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