Rabbit anti-Human ILPIP Polyclonal Antibody | anti-ILPIP antibody

ILPIP Antibody

Cat. Num. AAA9408397

• Gene Names: STRADB; PAPK; ILPIP; ILPIPA; ALS2CR2; CALS-21; PRO1038
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: ILPIP; Polyclonal Antibody; ILPIP Antibody; anti-ILPIP antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Anti-ILPIP is specific for human ILPIP only.
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 418

• Applicable Applications for anti-ILPIP antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a synthetic peptide corresponding to amino acids at the C-terminus of human ILPIP.
• Target Name: ILPIP
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of ILPIP in human heart lysate with ILPIP antibody at 0.5 (lane A), 1 (lane B), and 2 (lane C) ug/mL, respectively.)

Immunohistochemistry (IHC)

(Immunohistochemistry of ILPIP in human heart tissue with ILPIP antibody at 5 ug/mL.)

Related Product Information for anti-ILPIP antibody

ILPIP (ILP-interacting protein) has recently been shown to interact with XIAP, a member of the IAP (Inhibitor of Apoptosis) protein family. Together, these two proteins synergistically activate the TAK1/JNK1 signal transduction pathway, which acts to protect against the interleukin-1b converting enzyme of Fas-induced apotosis. This protein was independently isolated and characterized as polyploidy-associated protein kinase (PAPK), a member of the Ste20/germinal center kinase family that modulates cytoskeletal organization and cell survival, suggesting that its protective role may be a function of its kinase activity. Although two mRNA sequences have been isolated, only the shorter isoform has been observed.

Product Categories/Family for anti-ILPIP antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 13027388
• NCBI GeneID: 55437
• NCBI Accession #: NP_061041
• NCBI GenBank Nucleotide #: NM_018571.5
• Molecular Weight: 31,219 Da
• NCBI Official Full Name: STE20-related kinase adapter protein beta isoform 1
• NCBI Official Synonym Full Names: STE20-related kinase adaptor beta
• NCBI Official Symbol: STRADB
• NCBI Official Synonym Symbols: PAPK; ILPIP; ILPIPA; ALS2CR2; CALS-21; PRO1038
• NCBI Protein Information: STE20-related kinase adapter protein beta
• UniProt Protein Name: STE20-related kinase adapter protein beta
• UniProt Gene Name: STRADB
• UniProt Synonym Gene Names: ALS2CR2; ILPIP; STRAD beta
• UniProt Entry Name: STRAB_HUMAN

NCBI Description

This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Uniprot Description

STLK6: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, STE; Motility/polarity/chemotaxis; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; STLK subfamily

Chromosomal Location of Human Ortholog: 2q33.1

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: protein binding; ATP binding; receptor signaling protein serine/threonine kinase activity; protein kinase activity

Biological Process: insulin receptor signaling pathway; cell morphogenesis; activation of protein kinase activity; JNK cascade; protein export from nucleus; mitotic cell cycle; cell cycle arrest; protein amino acid phosphorylation