Rabbit anti-Human SLC34A3 Polyclonal Antibody | anti-SLC34A3 antibody

SLC34A3 Antibody

Cat. Num. AAA9405863

• Gene Names: SLC34A3; HHRH; NPTIIc
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: SLC34A3; Polyclonal Antibody; SLC34A3 Antibody; HHRH; NPTIIc; anti-SLC34A3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total SLC34A3 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 2.6 mg/ml (varies by lot)
• Sequence Length: 599

• Applicable Applications for anti-SLC34A3 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:25-1:100
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human solute carrier family 34 (type II sodium/phosphate contransporter), member 3
• Target Name: SLC34A3
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human prostate cancer tissue using at dilution 1/20.)

Related Product Information for anti-SLC34A3 antibody

This gene encodes a member of SLC34A transporter family of proteins, and is expressed primarily in the kidney. It is involved in transporting phosphate into cells via sodium cotransport in the renal brush border membrane, and contributes to the maintenance of inorganic phosphate concentration in the kidney. Mutations in this gene are associated with hereditary hypophosphatemic rickets with hypercalciuria. Alternatively spliced transcript variants varying in the 5' UTR have been found for this gene.

Product Categories/Family for anti-SLC34A3 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 293597523
• NCBI GeneID: 142680
• NCBI Accession #: NP_001170787.1
• NCBI GenBank Nucleotide #: NM_001177316.1
• UniProt Accession #: Q8N130; A2BFA1
• Molecular Weight: 63,550 Da
• NCBI Official Full Name: sodium-dependent phosphate transport protein 2C
• NCBI Official Synonym Full Names: solute carrier family 34 (type II sodium/phosphate cotransporter), member 3
• NCBI Official Symbol: SLC34A3
• NCBI Official Synonym Symbols: HHRH; NPTIIc
• NCBI Protein Information: sodium-dependent phosphate transport protein 2C
• UniProt Protein Name: Sodium-dependent phosphate transport protein 2C
• Protein Family: Sodium-dependent phosphate transport protein
• UniProt Gene Name: SLC34A3
• UniProt Synonym Gene Names: NPT2C; NPTIIC; Sodium-phosphate transport protein 2C; Na(+)/Pi cotransporter 2C; NaPi-2c
• UniProt Entry Name: NPT2C_HUMAN

NCBI Description

This gene encodes a member of SLC34A transporter family of proteins, and is expressed primarily in the kidney. It is involved in transporting phosphate into cells via sodium cotransport in the renal brush border membrane, and contributes to the maintenance of inorganic phosphate concentration in the kidney. Mutations in this gene are associated with hereditary hypophosphatemic rickets with hypercalciuria. Alternatively spliced transcript variants varying in the 5' UTR have been found for this gene.[provided by RefSeq, Apr 2010]

Uniprot Description

SLC34A3: May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 20-30% of the apical influx. Defects in SLC34A3 are the cause of hereditary hypophosphatemic rickets with hypercalciuria (HHRH). HHRH is an autosomal recessive form of hypophosphatemia characterized by reduced renal phosphate reabsorption and rickets. Increased serum levels of 1,25-dihydroxyvitamin D lead to increase in urinary calcium excretion. Belongs to the SLC34A transporter family.

Protein type: Transporter, SLC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: brush border membrane; apical plasma membrane; plasma membrane; integral to membrane

Molecular Function: sodium-dependent phosphate transmembrane transporter activity; sodium:phosphate symporter activity

Biological Process: cellular phosphate ion homeostasis; phosphate transport; sodium ion transport; ion transport; transmembrane transport

Disease: Hypophosphatemic Rickets With Hypercalciuria, Hereditary