Rabbit SLC1A4 Polyclonal Antibody | anti-SLC1A4 antibody

SLC1A4 antibody

Cat. Num. AAA9402532

• Gene Names: SLC1A4; SATT; ASCT1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: SLC1A4; Polyclonal Antibody; SLC1A4 antibody; ASCT1; SATT; anti-SLC1A4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total SLC1A4 antibody.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 234

• Applicable Applications for anti-SLC1A4 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Western blotting: 1:500 - 1:2000; Immunohistochemistry: 1:50 - 1:200
• Immunogen Type: Peptide
• Immunogen Description: A synthetic peptide of human SLC1A4.
• Target Name: SLC1A4
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts of HepG2 cell lines, using SLC1A4 antibody.)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human ovarian cancer tissue, using SLC1A4 antibody.)

Related Product Information for anti-SLC1A4 antibody

SLC1A4, also known as ASCT1, is a neutral amino acid transporter. Its other name, ASCT1, was given because it mediates obligatory exchange of alanine, serine, cysteine, and threonine (1). SLC1A4 mediates the efflux of glutamate from the neuron into the synaptic junction via calcium-independent release, as well as mediating the efflux of L-serine from glial cells and its uptake by neurons (2). SLC1A4-mediated transport is shown to involve a symmetrical potassium-independent electroneutral exchange of neutral amino acids and sodium, such that the current activated during transport is carried only by chloride ions (3).

Product Categories/Family for anti-SLC1A4 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 301601644
• NCBI GeneID: 6509
• NCBI Accession #: NP_001180422.1
• NCBI GenBank Nucleotide #: NM_001193493.1
• UniProt Accession #: P43007; B7Z3C0; D6W5F0
• Molecular Weight: 24,620 Da
• NCBI Official Full Name: neutral amino acid transporter A isoform 2
• NCBI Official Synonym Full Names: solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
• NCBI Official Symbol: SLC1A4
• NCBI Official Synonym Symbols: SATT; ASCT1
• NCBI Protein Information: neutral amino acid transporter A
• UniProt Protein Name: Neutral amino acid transporter A
• Protein Family: Neutral amino acid transporter
• UniProt Gene Name: SLC1A4
• UniProt Synonym Gene Names: ASCT1; SATT; ASCT-1
• UniProt Entry Name: SATT_HUMAN

Uniprot Description

SLC1A4: Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence. Expressed mostly in brain, muscle, and pancreas but detected in all tissues examined. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A4 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Transporter, SLC family; Transporter; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2p15-p13

Cellular Component: centrosome; cell surface; membrane; cell soma; integral to plasma membrane; dendrite; melanosome; integral to membrane; plasma membrane; intermediate filament; microtubule organizing center

Molecular Function: L-serine transmembrane transporter activity; chloride channel activity; L-threonine transmembrane transporter activity; L-proline transmembrane transporter activity; L-alanine transmembrane transporter activity; sodium:dicarboxylate symporter activity; L-cystine transmembrane transporter activity; L-glutamine transmembrane transporter activity

Biological Process: synaptic transmission, glutamatergic; threonine transport; L-cystine transport; chloride transport; L-serine transport; L-alanine transport; amino acid transport; dicarboxylic acid transport; ion transport; proline transport; cognition; glutamine transport; transmembrane transport