Testing Data
(Sample(30 ug whole cell lysate)A: Raji 5% SDS PAGEPrimary antibody diluted at 1: 1000)
Rabbit anti-Human Flightless I Polyclonal Antibody | anti-FLII antibody
Flightless I antibody
Immunofluorescence: 1:100-1:200
Testing Data
(Sample(30 ug whole cell lysate)A: Raji 5% SDS PAGEPrimary antibody diluted at 1: 1000)
Testing Data
(Sample(30 ug whole cell lysate)A: Raji 5% SDS PAGEPrimary antibody diluted at 1: 1000)
Immunofluorescence (IF)
(A:Immunofluorescence analysis of paraformaldehyde-fixed mouse ESC D3, using Flightless I antibody at 1: 200 dilution. B:Confocal immunofluorescence analysis (Olympus FV10i) of paraformaldehyde-fixed HeLa, using Flightless I antibody (Green) at 1: 500 dilution and alpha-tubulin antibody (Red) at 1: 2000.)
Immunofluorescence (IF)
(A:Immunofluorescence analysis of paraformaldehyde-fixed mouse ESC D3, using Flightless I antibody at 1: 200 dilution. B:Confocal immunofluorescence analysis (Olympus FV10i) of paraformaldehyde-fixed HeLa, using Flightless I antibody (Green) at 1: 500 dilution and alpha-tubulin antibody (Red) at 1: 2000.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Uniprot Description
FLI: May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development. May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration. Deletion of the FLII gene may be a cause of Smith-Magenis syndrome (SMS). It is a contiguous gene deletion syndrome involving developmental abnormalities and mental retardation. The spectrum of clinical findings includes short stature, brachydactyly, developmental delay, dysmorphic features, sleep disturbances, and behavioral problems.
Protein type: Nuclear receptor co-regulator; Actin-binding
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component: nucleoplasm; focal adhesion; cytoplasm; microtubule organizing center
Molecular Function: protein binding; actin binding
Biological Process: actin filament severing; muscle contraction; regulation of transcription, DNA-dependent; transcription, DNA-dependent; multicellular organismal development; actin cytoskeleton organization and biogenesis
Disease: Smith-magenis Syndrome
Research Articles on FLII
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Product Notes
The FLII flii (Catalog #AAA9402066) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Flightless I antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Flightless I can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF). Western blotting: 1:500-1:3000 Immunofluorescence: 1:100-1:200. Researchers should empirically determine the suitability of the FLII flii for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Flightless I, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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