Rabbit KCND2 Polyclonal Antibody | anti-KCND2 antibody

KCND2 antibody

Cat. Num. AAA9401730

• Gene Names: KCND2; RK5; KV4.2
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: KCND2; Polyclonal Antibody; KCND2 antibody; RK5; KV4.2; anti-KCND2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total KCND2 antibody.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 630

• Applicable Applications for anti-KCND2 antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:500 - 1:2000
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant protein of human KCND2.
• Target Name: KCND2
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using KCND2 antibody.)

Related Product Information for anti-KCND2 antibody

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels.

Product Categories/Family for anti-KCND2 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 9789987
• NCBI GeneID: 3751
• NCBI Accession #: NP_036413.1
• NCBI GenBank Nucleotide #: NM_012281.2
• UniProt Accession #: Q9NZV8; O95012; O95021; Q2TBD3; Q9UBY7; Q9UN98; Q9UNH9
• Molecular Weight: 70,537 Da
• NCBI Official Full Name: potassium voltage-gated channel subfamily D member 2
• NCBI Official Synonym Full Names: potassium channel, voltage gated Shal related subfamily D, member 2
• NCBI Official Symbol: KCND2
• NCBI Official Synonym Symbols: RK5; KV4.2
• NCBI Protein Information: potassium voltage-gated channel subfamily D member 2
• UniProt Protein Name: Potassium voltage-gated channel subfamily D member 2
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: KCND2
• UniProt Synonym Gene Names: KIAA1044
• UniProt Entry Name: KCND2_HUMAN

NCBI Description

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels. [provided by RefSeq, Jul 2008]

Uniprot Description

Kv4.2: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.

Protein type: Channel, potassium; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q31

Cellular Component: postsynaptic membrane; voltage-gated potassium channel complex; integral to plasma membrane; plasma membrane; integral to membrane; dendritic spine; intrinsic to plasma membrane

Molecular Function: voltage-gated potassium channel activity; protein binding; delayed rectifier potassium channel activity; metal ion binding; A-type (transient outward) potassium channel activity

Biological Process: regulation of action potential; synaptic transmission; protein homooligomerization