Rabbit anti-Human KCND2 Polyclonal Antibody | anti-KCND2 antibody

KCND2, NT (KCND2, KIAA1044, Potassium voltage-gated channel subfamily D member 2, Voltage-gated potassium channel subunit Kv4.2) (Azide free) (HRP)

Cat. Num. AAA6312361

• Gene Names: KCND2; RK5; KV4.2
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: KCND2; Polyclonal Antibody; NT (KCND2; KIAA1044; Potassium voltage-gated channel subfamily D member 2; Voltage-gated potassium channel subunit Kv4.2) (Azide free) (HRP); Voltage-gated potassium channel subunit Kv4.2; anti-KCND2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-KCND2 antibody: Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
• Application Notes: IHC: 1:10-50; ELISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: KCND2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-151 amino acids from the N-terminal region of human KCND2.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(KCND2 Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the KCND2 antibody detected the KCND2 protein (arrow).)

Immunohistochemistry (IHC)

(KCND2 Antibody (N-term) (AP14832a)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of KCND2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-KCND2 antibody

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes-shaker, shaw, shab, and shal-have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels.

Product Categories/Family for anti-KCND2 antibody

Antibodies; KIAA; orf

References

Foeger, N.C., et al. J. Biol. Chem. 285(43):33413-33422(2010). Levy, D.I., et al. J. Physiol. (Lond.) 588 (PT 14), 2657-2668 (2010): Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Aronica, E., et al. Neurobiol. Dis. 36(1):81-95(2009). Tayo, B.O., et al. Circ Cardiovasc Genet 2(1):38-45(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 9789987
• NCBI GeneID: 3751
• NCBI Accession #: NP_036413.1
• NCBI GenBank Nucleotide #: NM_012281.2
• UniProt Accession #: Q9NZV8; O95012; O95021; Q2TBD3; Q9UBY7; Q9UN98; Q9UNH9
• Molecular Weight: 70,537 Da
• NCBI Official Full Name: potassium voltage-gated channel subfamily D member 2
• NCBI Official Synonym Full Names: potassium voltage-gated channel, Shal-related subfamily, member 2
• NCBI Official Symbol: KCND2
• NCBI Official Synonym Symbols: RK5; KV4.2
• NCBI Protein Information: potassium voltage-gated channel subfamily D member 2; voltage-sensitive potassium channel; voltage-gated potassium channel subunit Kv4.2
• UniProt Protein Name: Potassium voltage-gated channel subfamily D member 2
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: KCND2
• UniProt Synonym Gene Names: KIAA1044
• UniProt Entry Name: KCND2_HUMAN

NCBI Description

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels. [provided by RefSeq, Jul 2008]

Uniprot Description

Kv4.2: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, potassium

Chromosomal Location of Human Ortholog: 7q31

Cellular Component: postsynaptic membrane; voltage-gated potassium channel complex; integral to plasma membrane; integral to membrane; plasma membrane; dendritic spine; intrinsic to plasma membrane

Molecular Function: protein binding; voltage-gated potassium channel activity; delayed rectifier potassium channel activity; metal ion binding; A-type (transient outward) potassium channel activity

Biological Process: regulation of action potential; synaptic transmission; protein homooligomerization