Hamster N-Acylsphingosine Amidohydrolase 2 (ASAH2) ELISA Kit | ASAH2 elisa kit
Hamster N-Acylsphingosine Amidohydrolase 2 (ASAH2) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger (see MIM 603730) (Mitsutake et al., 2001 [PubMed 11328816]).[supplied by OMIM, Mar 2008]
Uniprot Description
ASAH2: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract. Belongs to the neutral ceramidase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.5.1.23; Hydrolase; Lipid Metabolism - sphingolipid; Membrane protein, integral
Chromosomal Location of Human Ortholog: 10q11.23
Cellular Component: mitochondrion
Biological Process: ceramide metabolic process; signal transduction
Research Articles on ASAH2
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Product Notes
The Hamster ASAH2 asah2 (Catalog #AAA9391164) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9391164 ELISA Kit recognizes Hamster ASAH2. It is sometimes possible for the material contained within the vial of "N-Acylsphingosine Amidohydrolase 2 (ASAH2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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