PRTN3 (203S/A, His) Recombinant Protein | PRTN3 recombinant protein

PRTN3 Protein, Human, Recombinant (203S/A, His Tag)

Cat. Num. AAA8118685

• Gene Names: PRTN3; MBN; MBT; NP4; P29; PR3; ACPA; AGP7; NP-4; PR-3; CANCA; C-ANCA
• Purity: >95 % as determined by SDS-PAGE.
• Synonyms: PRTN3 (203S/A; His); PRTN3 Protein; Human; Recombinant (203S/A; His Tag); Human PRTN3 Protein (203S/A; proteinase 3; ACPA Protein; AGP7 Protein; C-ANCA Protein; CANCA Protein; MBN Protein; MBT Protein; NP-4 Protein; NP4 Protein; P29 Protein; PR-3 Protein; PR3 Protein; PRTN3 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95 % as determined by SDS-PAGE.
• Form/Format: Lyophilized from sterile PBS, pH7.4 Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Sequence Positions: 240aa
• Sequence: Ile28-Pro526

• Species: Human
• Tag: C-His
• Endotoxin: <1.0EU per ug protein as determined by the LAL method
• Predicted N Terminal: Ile28
• Protein Construction: |A DNA sequence encoding the human PRTN3 (NP_002768.3, with mutation Ser 203 Ala) (Ile28-Pro526) was expressed with a polyhistide tag at the C-terminus.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; Shipping: They are shipped out with blue ice pack

Testing Data

Product Categories/Family for PRTN3 recombinant protein

Serine Proteases and Regulators

NCBI and Uniprot Product Information

• NCBI GI #: 71361688
• NCBI GeneID: 5657
• NCBI Accession #: NP_002768.3
• NCBI GenBank Nucleotide #: NM_002777.3
• UniProt Accession #: P24158; P15637; P18078; Q4VB08; Q4VB09; Q6LBM7; Q6LBN2; Q9UD25; Q9UQD8
• Molecular Weight: 27,807 Da
• NCBI Official Full Name: myeloblastin
• NCBI Official Synonym Full Names: proteinase 3
• NCBI Official Symbol: PRTN3
• NCBI Official Synonym Symbols: MBN; MBT; NP4; P29; PR3; ACPA; AGP7; NP-4; PR-3; CANCA; C-ANCA
• NCBI Protein Information: myeloblastin; C-ANCA antigen; wegener autoantigen; leukocyte proteinase 3; neutrophil proteinase 4; azurophil granule protein 7; serine proteinase, neutrophil; Wegener granulomatosis autoantigen
• UniProt Protein Name: Myeloblastin
• Protein Family: Myeloblastin
• UniProt Gene Name: PRTN3
• UniProt Synonym Gene Names: MBN; PR-3; PR3; NP-4
• UniProt Entry Name: PRTN3_HUMAN

Uniprot Description

PRTN3: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters. Belongs to the peptidase S1 family. Elastase subfamily.

Protein type: Protease; Cell cycle regulation; EC 3.4.21.76

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: extracellular matrix; extracellular space; plasma membrane; cytosol

Molecular Function: enzyme binding; serine-type peptidase activity; serine-type endopeptidase activity

Biological Process: negative regulation of phagocytosis; collagen catabolic process; positive regulation of cell proliferation; blood coagulation; proteolysis