Plant Activated Protein C (APC) ELISA Kit | APC elisa kit

Plant Activated Protein C (APC) ELISA Kit

• Gene Names: APC; GS; DP2; DP3; BTPS2; DP2.5; PPP1R46
• Reactivity: Plant
• Synonyms: Activated Protein C (APC); Plant Activated Protein C (APC) ELISA Kit; APC elisa kit

• Reactivity: Plant
• Sequence Length: 2843

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 182397
• NCBI GeneID: 324
• Molecular Weight: 300,439 Da
• NCBI Official Full Name: APC
• NCBI Official Synonym Full Names: APC, WNT signaling pathway regulator
• NCBI Official Symbol: APC
• NCBI Official Synonym Symbols: GS; DP2; DP3; BTPS2; DP2.5; PPP1R46
• NCBI Protein Information: adenomatous polyposis coli protein
• UniProt Protein Name: Adenomatous polyposis coli protein
• Protein Family: Adenomatous polyposis coli
• UniProt Gene Name: APC
• UniProt Synonym Gene Names: DP2.5; Protein APC
• UniProt Entry Name: APC_HUMAN

NCBI Description

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]

Uniprot Description

APC: a tumor suppressor. Defects in APC are a cause of familial adenomatous polyposis (FAP). Promotes rapid degradation of CTNNB1 and participates in Wnt signaling. Activity is correlated with its phosphorylation state. Two splice-variant isoforms have been described.

Protein type: Tumor suppressor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5q21-q22

Cellular Component: beta-catenin destruction complex; catenin complex; cell-cell adherens junction; centrosome; cytoplasm; cytoplasmic microtubule; cytosol; kinetochore; lamellipodium; lateral plasma membrane; nucleoplasm; nucleus; plasma membrane; tight junction

Molecular Function: beta-catenin binding; cadherin binding; gamma-catenin binding; microtubule binding; microtubule plus-end binding; protein binding; protein kinase binding; protein kinase regulator activity

Biological Process: cell cycle arrest; cell fate specification; cell migration; cell structure disassembly during apoptosis; cytokinesis after mitosis; mitotic cell cycle spindle assembly checkpoint; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of microtubule depolymerization; pattern specification process; positive regulation of apoptosis; positive regulation of cell migration; positive regulation of protein catabolic process; positive regulation of pseudopodium formation; proteasomal ubiquitin-dependent protein catabolic process; protein complex assembly; regulation of attachment of spindle microtubules to kinetochore; regulation of cell differentiation; regulation of microtubule-based process; response to DNA damage stimulus; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin

Disease: Colorectal Cancer; Desmoid Disease, Hereditary; Familial Adenomatous Polyposis 1; Gastric Cancer; Hepatocellular Carcinoma