Immunohistochemistry (IHC)-Paraffin
(The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using MBS7123183(COX6B1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200))
Rabbit anti-Human, Mouse COX6B1 Polyclonal Antibody | anti-COX6B1 antibody
COX6B1 Antibody
WB: 1:1000-1:5000
IHC: 1:50-1:200
Immunohistochemistry (IHC)-Paraffin
(The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using MBS7123183(COX6B1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200))
Immunohistochemistry (IHC)-Paraffin
(The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using MBS7123183(COX6B1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200))
Immunohistochemistry (IHC)-Paraffin
(The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using MBS7123183(COX6B1 Antibody) at dilution 1/50. (Original magnification: ×200))
Immunohistochemistry (IHC)-Paraffin
(The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using MBS7123183(COX6B1 Antibody) at dilution 1/50. (Original magnification: ×200))
SDS-Page
(Gel: 10%SDS-PAGE, Lysate: 40 ug, Lane 1-3: Mouse heart tissue, human fetal liver tissue, Human hepatocellular carcinoma tissue, Primary antibody: MBS7123183(COX6B1 Antibody) at dilution 1/1150, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute)
SDS-Page
(Gel: 10%SDS-PAGE, Lysate: 40 ug, Lane 1-3: Mouse heart tissue, human fetal liver tissue, Human hepatocellular carcinoma tissue, Primary antibody: MBS7123183(COX6B1 Antibody) at dilution 1/1150, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute)
NCBI and Uniprot Product Information
NCBI Description
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIb. Mutations in this gene are associated with severe infantile encephalomyopathy. Three pseudogenes COX6BP-1, COX6BP-2 and COX6BP-3 have been found on chromosomes 7, 17 and 22q13.1-13.2, respectively. [provided by RefSeq, Jan 2010]
Uniprot Description
COX6B1: Connects the two COX monomers into the physiological dimeric form. Defects in COX6B1 are a cause of mitochondrial complex IV deficiency (MT-C4D); also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome. Belongs to the cytochrome c oxidase subunit 6B family.
Protein type: Mitochondrial; Energy Metabolism - oxidative phosphorylation
Chromosomal Location of Human Ortholog: 19q13.1
Cellular Component: mitochondrion; mitochondrial inner membrane; mitochondrial intermembrane space
Molecular Function: cytochrome-c oxidase activity
Biological Process: cellular metabolic process; substantia nigra development; transmembrane transport
Disease: Mitochondrial Complex Iv Deficiency
Research Articles on COX6B1
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Product Notes
The COX6B1 cox6b1 (Catalog #AAA7123183) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The COX6B1 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's COX6B1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). ELISA: 1:500-1:5000 WB: 1:1000-1:5000 IHC: 1:50-1:200. Researchers should empirically determine the suitability of the COX6B1 cox6b1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "COX6B1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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