Porcine Membrane-Bound Transcription Factor Site-1 Protease (MBTPS1) ELISA Kit | MBTPS1 elisa kit
Porcine Membrane-Bound Transcription Factor Site-1 Protease (MBTPS1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction. [provided by RefSeq, Feb 2014]
Uniprot Description
MBTPS1: Catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His- Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Belongs to the peptidase S8 family.
Protein type: Membrane protein, integral; Protease; Endoplasmic reticulum; EC 3.4.21.112
Chromosomal Location of Human Ortholog: 16q24
Cellular Component: endoplasmic reticulum lumen; endoplasmic reticulum membrane; Golgi membrane; Golgi stack; integral to membrane
Molecular Function: serine-type endopeptidase activity
Biological Process: cellular protein metabolic process; cholesterol metabolic process; lysosome organization and biogenesis; membrane protein intracellular domain proteolysis; proteolysis; regulation of transcription factor import into nucleus; unfolded protein response
Research Articles on MBTPS1
Similar Products
Product Notes
The Porcine MBTPS1 mbtps1 (Catalog #AAA9363779) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9363779 ELISA Kit recognizes Porcine MBTPS1. It is sometimes possible for the material contained within the vial of "Membrane-Bound Transcription Factor Site-1 Protease (MBTPS1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
