Hamster Solute Carrier Organic Anion Transporter Family Member 1B3 (SLCO1B3) ELISA Kit | SLCO1B3 elisa kit
Hamster Solute Carrier Organic Anion Transporter Family Member 1B3 (SLCO1B3) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. [provided by RefSeq, Feb 2012]
Uniprot Description
SLCO1B3: Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP).Involved in the clearance of bile acids and organic anions from the liver. Defects in SLCO1B3 are a cause of hyperbilirubinemia, Rotor type (HBLRR). An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal. Belongs to the organo anion transporter (TC 2.A.60) family.
Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 12p12
Cellular Component: basolateral plasma membrane; integral to plasma membrane; plasma membrane
Molecular Function: bile acid transmembrane transporter activity; organic anion transmembrane transporter activity; sodium-independent organic anion transmembrane transporter activity
Biological Process: bile acid and bile salt transport; bile acid metabolic process; organic anion transport; sodium-independent organic anion transport; transmembrane transport
Disease: Hyperbilirubinemia, Rotor Type
Research Articles on SLCO1B3
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Product Notes
The Hamster SLCO1B3 slco1b3 (Catalog #AAA9361707) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9361707 ELISA Kit recognizes Hamster SLCO1B3. It is sometimes possible for the material contained within the vial of "Solute Carrier Organic Anion Transporter Family Member 1B3 (SLCO1B3), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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