Human interphotoreceptor matrix proteoglycan 2 ELISA Kit | IMPG2 elisa kit
Human Interphotoreceptor matrix proteoglycan 2, IMPG2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene binds chondroitin sulfate and hyaluronan and is a proteoglycan. The encoded protein plays a role in the organization of the interphotoreceptor matrix and may promote the growth and maintenance of the light-sensitive photoreceptor outer segment. Defects in this gene are a cause of retinitis pigmentosa type 56 and maculopathy, IMPG2-related.[provided by RefSeq, Mar 2011]
Uniprot Description
IMPG2: Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light- sensitive photoreceptor outer segment. Binds heparin. Defects in IMPG2 are the cause of retinitis pigmentosa type 56 (RP56). RP56 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Defects in IMPG2 are the cause of maculopathy IMPG2- related (MACLP-IMPG2). MACLP-IMPG2 is a mild maculopathy characterized by full-field electroretinogram responses within normal limits, normal color vision, elevation of the photoreceptor layer in the foveal region and mild nuclear sclerosis.
Protein type: Extracellular matrix; Membrane protein, integral
Chromosomal Location of Human Ortholog: 3q12.2-q12.3
Cellular Component: proteinaceous extracellular matrix; integral to membrane; receptor complex
Molecular Function: heparin binding; extracellular matrix structural constituent; hyaluronic acid binding
Biological Process: visual perception
Disease: Retinitis Pigmentosa 56; Macular Dystrophy, Vitelliform, 5
Research Articles on IMPG2
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Product Notes
The Human IMPG2 impg2 (Catalog #AAA9343052) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9343052 ELISA Kit recognizes Human IMPG2. It is sometimes possible for the material contained within the vial of "interphotoreceptor matrix proteoglycan 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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