Human PR domain containing 6 ELISA Kit | PRDM6 elisa kit
Human Putative histone-lysine N-methyltransferase PRDM6, PRDM6 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
PRDM6: Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.1.1.43; Cell development/differentiation; Methyltransferase; Methyltransferase, protein lysine; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 5q23.2
Cellular Component: nucleus
Molecular Function: protein homodimerization activity; nucleic acid binding; metal ion binding; histone-lysine N-methyltransferase activity
Biological Process: neurogenesis; transcription, DNA-dependent; negative regulation of smooth muscle cell differentiation; negative regulation of transcription, DNA-dependent
Research Articles on PRDM6
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Product Notes
The Human PRDM6 prdm6 (Catalog #AAA9341693) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9341693 ELISA Kit recognizes Human PRDM6. It is sometimes possible for the material contained within the vial of "PR domain containing 6, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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