Western Blot (WB)
(Western blot analysis of PRDM6 expression in Jurkat (A), MCF7 (B), mouse lung (C) whole cell lysates.)
Rabbit anti-Human, Mouse PRDM6 Polyclonal Antibody | anti-PRDM6 antibody
Anti-PRDM6 Antibody
Western Blot (WB)
(Western blot analysis of PRDM6 expression in Jurkat (A), MCF7 (B), mouse lung (C) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of PRDM6 expression in Jurkat (A), MCF7 (B), mouse lung (C) whole cell lysates.)
NCBI and Uniprot Product Information
Uniprot Description
PRDM6: Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: C2H2-type zinc finger protein; EC 2.1.1.43; Methyltransferase, protein lysine; Methyltransferase; Cell development/differentiation
Chromosomal Location of Human Ortholog: 5q23.2
Cellular Component: nucleus
Molecular Function: histone-lysine N-methyltransferase activity; metal ion binding; nucleic acid binding; protein homodimerization activity
Biological Process: negative regulation of smooth muscle cell differentiation; negative regulation of transcription, DNA-dependent; neurogenesis; transcription, DNA-dependent
Research Articles on PRDM6
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Product Notes
The PRDM6 prdm6 (Catalog #AAA8245221) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-PRDM6 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's PRDM6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1/500 - 1/2000. Researchers should empirically determine the suitability of the PRDM6 prdm6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PRDM6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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