Human ring finger protein 34 ELISA Kit | RNF34 elisa kit
Human E3 ubiquitin-protein ligase RNF34, RNF34 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]
Uniprot Description
RNF34: Has E3 ubiquitin-protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Protects cells against apoptosis induced by TNF. Binds phosphatidylinositol 5-phosphate and phosphatidylinositol 3- phosphate. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.-; Ligase
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component: cytoplasm; plasma membrane; endomembrane system; nuclear speck; nucleus; cytosol
Molecular Function: protein binding; zinc ion binding; p53 binding; ubiquitin protein ligase binding; ligase activity
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination during ubiquitin-dependent protein catabolic process; protein ubiquitination
Research Articles on RNF34
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Product Notes
The Human RNF34 rnf34 (Catalog #AAA9337722) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9337722 ELISA Kit recognizes Human RNF34. It is sometimes possible for the material contained within the vial of "ring finger protein 34, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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