Human SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae) ELISA Kit | SPO11 elisa kit
Human Meiotic recombination protein SPO11, SPO11 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008]
Uniprot Description
SPO11: Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. Belongs to the TOP6A family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cancer Testis Antigen (CTA); Cell cycle regulation; Cell development/differentiation
Chromosomal Location of Human Ortholog: 20q13.31
Cellular Component: chromosome, telomeric region; nucleus
Molecular Function: DNA binding; hydrolase activity; ATP binding
Biological Process: ovarian follicle development; male meiosis I; meiotic recombination; synapsis; female gamete generation; spermatogenesis; DNA catabolic process, endonucleolytic; spermatid development
Research Articles on SPO11
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Product Notes
The Human SPO11 spo11 (Catalog #AAA9337520) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9337520 ELISA Kit recognizes Human SPO11. It is sometimes possible for the material contained within the vial of "SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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