Rat EPH receptor A5 ELISA Kit | EPHA5 elisa kit
Rat Ephrin type-A receptor 5, EPHA5 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
receptor tyrosine kinase; may have a role in both the development and maintenance of differentiated neurons [RGD, Feb 2006]
Uniprot Description
EphA5: Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino- hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. Beside its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Protein kinase, tyrosine (receptor); Protein kinase, TK; EC 2.7.10.1; Kinase, protein; Membrane protein, integral; TK group; Eph family
Cellular Component: cell soma; rough endoplasmic reticulum; integral to plasma membrane; perinuclear region of cytoplasm; axon; dendrite; plasma membrane; integral to membrane; external side of plasma membrane
Molecular Function: protein binding; GPI-linked ephrin receptor activity; ephrin receptor activity; ATP binding
Biological Process: positive regulation of phosphoinositide 3-kinase cascade; axon guidance; cAMP-mediated signaling; peptidyl-tyrosine phosphorylation; regulation of actin cytoskeleton organization and biogenesis; hippocampus development; activation of CREB transcription factor; ephrin receptor signaling pathway; neuron development; negative regulation of synaptogenesis
Research Articles on EPHA5
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Product Notes
The Rat EPHA5 epha5 (Catalog #AAA9337139) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9337139 ELISA Kit recognizes Rat EPHA5. It is sometimes possible for the material contained within the vial of "EPH receptor A5, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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