Rat kalirin, RhoGEF kinase ELISA Kit | KALRN elisa kit
Rat Kalirin, KALRN ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
binds the human huntingtin associated protein Hap1 in vitro; has GDP/GTP exchange factor activity for Rho subfamily GTP-binding proteins [RGD, Feb 2006]
Uniprot Description
kalirin: a bifunctional enzyme with protein kinase activity and guanine-exchange factor (GEF) activity. A protein kinase of the CAMK group. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Genetic variants are associated with susceptibility to coronary heart disease type 5 (CHDS5), a multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1) Interacts with FASLG. The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity. 6 isoforms of the human protein are produced by alternative splicing. Isoform 2 is brain specific and is highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle.
Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); GEFs, Rac/Rho; Protein kinase, CAMK; Kinase, protein; GEFs; CAMK group; Trio family
Cellular Component: neuron projection; cytoskeleton; cell soma; perinuclear region of cytoplasm
Molecular Function: protein serine/threonine kinase activity; Rho guanyl-nucleotide exchange factor activity; protein binding; enzyme binding; metal ion binding; guanyl-nucleotide exchange factor activity; ATP binding
Biological Process: nervous system development; axonogenesis; regulation of dendrite development; protein amino acid phosphorylation; positive regulation of GTPase activity
Research Articles on KALRN
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Product Notes
The Rat KALRN kalrn (Catalog #AAA9337073) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9337073 ELISA Kit recognizes Rat KALRN. It is sometimes possible for the material contained within the vial of "kalirin, RhoGEF kinase, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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