Western Blot (WB)
(Western blot analysis of extracts of SW480 cell lines, using TIMP2 antibody.)
Rabbit TIMP2 Polyclonal Antibody | anti-TIMP2 antibody
TIMP2 Antibody
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry, Immunofluorescence
Purity
Antigen affinity purification
Synonyms
TIMP2; Polyclonal Antibody; TIMP2 Antibody; CSC-21K; anti-TIMP2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen affinity purification
Concentration
1mg/mL (varies by lot)
Sequence Length
129
Applicable Applications for anti-TIMP2 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Immunogen
Recombinant protein of human TIMP2
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Western Blot (WB)
(Western blot analysis of extracts of SW480 cell lines, using TIMP2 antibody.)
Western Blot (WB)
(Western blot analysis of extracts of SW480 cell lines, using TIMP2 antibody.)
Immunofluorescence (IF)
(Immunofluorescence analysis of MCF7 cell using TIMP2 antibody. Blue: DAPI for nuclear staining.)
Immunofluorescence (IF)
(Immunofluorescence analysis of MCF7 cell using TIMP2 antibody. Blue: DAPI for nuclear staining.)
Related Product Information for anti-TIMP2 antibody
TIMPs are members of the family of tissue inhibitor of matrix metalloproteinases (MMPs) that includes TIMP1, TIMP2, TIMP3, and TIMP4. The main function of TIMPs is their inhibitory effect on MMPs. TIMPs irreversibly inactivate MMPs by direct binding to their catalytic zinc cofactor and resultant inhibition of proteinase function (1, 2). In addition to MMP inhibition, TIMPs have also been shown to interact with various membrane receptors on the cell surface. Some of these interactions include: TIMP1 with CD63, TIMP2 with alpha3beta1 integrin, and TIMP3 with VEGFR2, all of which result in distinct cellular effects (3). TIMPs are involved in a wide variety of biological functions, such as tumor angiogenesis and progression (4, 5), wound healing, and vascular remodeling (6, 7). Mutations in TIMP3 are associated with Sorsby's fundus dystrophy (8, 9).
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
13,651 Da
NCBI Official Full Name
TIMP2; TIMP metallopeptidase inhibitor 2
UniProt Protein Name
TIMP2 TIMP metallopeptidase inhibitor 2
Protein Family
UniProt Gene Name
Amir_5100
UniProt Entry Name
C6WSA2_ACTMD
Similar Products
Product Notes
The TIMP2 amir_5100 (Catalog #AAA2522309) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TIMP2 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TIMP2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). Researchers should empirically determine the suitability of the TIMP2 amir_5100 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TIMP2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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