Mouse SET domain containing (lysine methyltransferase) 7 ELISA Kit | SETD7 elisa kit
Mouse Histone-lysine N-methyltransferase SETD7, SETD7 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
SETD7: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Interacts with IPF1/PDX-1. Widely expressed. Expressed in pancreatic islets. Belongs to the histone-lysine methyltransferase family. SET7 subfamily.
Protein type: Methyltransferase, protein lysine; Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase
Cellular Component: nucleolus; chromosome; nucleus
Molecular Function: transferase activity; methyltransferase activity; protein binding; p53 binding; protein-lysine N-methyltransferase activity; chromatin binding; histone-lysine N-methyltransferase activity
Biological Process: methylation; negative regulation of transferase activity; transcription, DNA-dependent; regulation of transcription, DNA-dependent; peptidyl-lysine di-methylation; positive regulation of transcription, DNA-dependent; peptidyl-lysine mono-methylation; chromatin modification; regulation of histone H3-K9 methylation; response to DNA damage stimulus; peptidyl-lysine methylation
Research Articles on SETD7
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Product Notes
The Mouse SETD7 setd7 (Catalog #AAA9334746) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9334746 ELISA Kit recognizes Mouse SETD7. It is sometimes possible for the material contained within the vial of "SET domain containing (lysine methyltransferase) 7, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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