Human ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 ELISA Kit | ATP6V1E1 elisa kit

Human V-type proton ATPase subunit E 1, ATP6V1E1 ELISA Kit

Cat. Num. AAA9332800

• Gene Names: ATP6V1E1; P31; Vma4; ATP6E; ATP6E2; ATP6V1E
• Reactivity: Human
• Synonyms: ATPase; H+ transporting; lysosomal 31kDa; V1 subunit E1; Human V-type proton ATPase subunit E 1; ATP6V1E1 ELISA Kit; Human V-type proton ATPase subunit E 1 (ATP6V1E1) ELISA kit; ATP6E; ATP6E2; ATP6V1E; P31; Vma4; H (+) -transporting two-sector ATPase; 31kDa subunit; H+-transporting ATP synthase chain E; vacuolar; V-ATPase; subunit E; vacuolar H+ ATPase E1; ATP6V1E1 elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 87159816
• NCBI GeneID: 529
• NCBI Accession #: NP_001034455.1
• NCBI GenBank Nucleotide #: NM_001039366.1
• UniProt Accession #: P36543; A8MUE4; A8MUN4
• Molecular Weight: 26,145 Da
• NCBI Official Full Name: V-type proton ATPase subunit E 1 isoform b
• NCBI Official Synonym Full Names: ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
• NCBI Official Symbol: ATP6V1E1
• NCBI Official Synonym Symbols: P31; Vma4; ATP6E; ATP6E2; ATP6V1E
• NCBI Protein Information: V-type proton ATPase subunit E 1; V-ATPase, subunit E; V-ATPase subunit E 1; V-ATPase 31 kDa subunit; vacuolar proton pump subunit E 1; H+-transporting ATP synthase chain E, vacuolar; H(+)-transporting two-sector ATPase, 31kDa subunit
• UniProt Protein Name: V-type proton ATPase subunit E 1
• UniProt Gene Name: ATP6V1E1
• UniProt Synonym Gene Names: ATP6E; ATP6E2; V-ATPase subunit E 1; p31
• UniProt Entry Name: VATE1_HUMAN

NCBI Description

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain E subunit isoforms. Pseudogenes for this gene have been found in the genome. [provided by RefSeq, Jul 2008]

Uniprot Description

ATP6V1E1: Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the V-ATPase E subunit family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; Mitochondrial; EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation

Chromosomal Location of Human Ortholog: 22q11.1

Cellular Component: microvillus; mitochondrion; lysosomal membrane; apical plasma membrane; proton-transporting two-sector ATPase complex; cytosol; endosome

Molecular Function: hydrogen-exporting ATPase activity, phosphorylative mechanism; protein binding; hydrogen ion transporting ATPase activity, rotational mechanism; ATPase binding

Biological Process: interaction with host; proton transport; metabolic process; cellular iron ion homeostasis; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; transmembrane transport