Rat calcium activated nucleotidase 1 ELISA Kit | CANT1 elisa kit
Rat Soluble calcium-activated nucleotidase 1, CANT1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
hydrolyzes nucleoside 5'-diphosphates in the order UDP >GDP = IDP >>>CDP but not ADP, may be involved in glycosylation reactions related to quality control in the endoplasmic reticulum [RGD, Feb 2006]
Uniprot Description
CANT1: Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis. Defects in CANT1 are the cause of Desbuquois dysplasia (DBQD). A chondrodysplasia characterized by severe prenatal and postnatal growth retardation (less than -5 SD), joint laxity, short extremities, progressive scoliosis, round face, midface hypoplasia, prominent bulging eyes. The main radiologic features are short long bones with metaphyseal splay, a 'Swedish key' appearance of the proximal femur (exaggerated trochanter), and advance carpal and tarsal bone age. Two forms of Desbuquois dysplasia are distinguished on the basis of the presence (type 1) or absence (type 2) of characteristic hand anomalies: an extra ossification center distal to the second metacarpal, delta phalanx, bifid distal thumb phalanx, and phalangeal dislocations. Belongs to the apyrase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Hydrolase; Nucleotide Metabolism - pyrimidine; Endoplasmic reticulum; Membrane protein, integral; EC 3.6.1.6; Nucleotide Metabolism - purine
Cellular Component: endoplasmic reticulum membrane; integral to membrane
Molecular Function: signal transducer activity; calcium ion binding; uridine-diphosphatase activity
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; proteoglycan biosynthetic process; signal transduction
Research Articles on CANT1
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Product Notes
The Rat CANT1 cant1 (Catalog #AAA9331869) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9331869 ELISA Kit recognizes Rat CANT1. It is sometimes possible for the material contained within the vial of "calcium activated nucleotidase 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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