Human RAS guanyl releasing protein 1 (calcium and DAG-regulated) ELISA Kit | RASGRP1 elisa kit
Human RAS guanyl-releasing protein 1, RASGRP1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]
Uniprot Description
RASGRP1: Functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Couples T-lymphocytes and B-lymphocytes antigen receptors to the activation of Ras. Hence, regulates T-cells and B-cells development, homeostasis and differentiation. Functions also in FcERI-evoked degranulation and cytokine secretion by mast cells, regulating allergic responses. May also function in other cell types differentiation. Defects in RASGRP1 may contribute to susceptibility to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. SLE is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Aberrantly spliced isoforms and/or diminished levels of RASGRP1 are found in a cohort of SLE patients raising the possibility that dysregulation of this signaling protein contributes to the development of autoimmunity in a subset of SLE patients. Belongs to the RASGRP family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs, Ras; GEFs
Chromosomal Location of Human Ortholog: 15q14
Cellular Component: Golgi membrane; endoplasmic reticulum membrane; mast cell granule; membrane; plasma membrane; cytosol
Molecular Function: guanyl-nucleotide exchange factor activity; calcium ion binding; lipid binding
Biological Process: platelet activation; inflammatory response to antigenic stimulus; Ras protein signal transduction; regulation of phosphoinositide 3-kinase cascade; vesicle transport along microtubule; innate immune response; cytokine production; mast cell degranulation; signal transduction; cell differentiation; blood coagulation; secretory granule localization
Research Articles on RASGRP1
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Product Notes
The Human RASGRP1 rasgrp1 (Catalog #AAA9331756) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9331756 ELISA Kit recognizes Human RASGRP1. It is sometimes possible for the material contained within the vial of "RAS guanyl releasing protein 1 (calcium and DAG-regulated), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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