Immunofluorescence (IF)
(Immunofluorescent analysis of HepG2 cells using MBS7048988 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
Rabbit anti-Human RASGRP1 Polyclonal Antibody | anti-RASGRP1 antibody
RASGRP1 Antibody
Immunofluorescence (IF)
(Immunofluorescent analysis of HepG2 cells using MBS7048988 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
Immunofluorescence (IF)
(Immunofluorescent analysis of HepG2 cells using MBS7048988 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]
Uniprot Description
RASGRP1: Functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Couples T-lymphocytes and B-lymphocytes antigen receptors to the activation of Ras. Hence, regulates T-cells and B-cells development, homeostasis and differentiation. Functions also in FcERI-evoked degranulation and cytokine secretion by mast cells, regulating allergic responses. May also function in other cell types differentiation. Defects in RASGRP1 may contribute to susceptibility to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. SLE is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Aberrantly spliced isoforms and/or diminished levels of RASGRP1 are found in a cohort of SLE patients raising the possibility that dysregulation of this signaling protein contributes to the development of autoimmunity in a subset of SLE patients. Belongs to the RASGRP family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs; GEFs, Ras
Chromosomal Location of Human Ortholog: 15q14
Cellular Component: cytosol; Golgi apparatus; membrane; plasma membrane
Molecular Function: calcium ion binding; diacylglycerol binding; guanyl-nucleotide exchange factor activity; lipid binding; phosphatidylcholine binding; phosphatidylserine binding; protein homodimerization activity; Ras guanyl-nucleotide exchange factor activity; zinc ion binding
Biological Process: MAPKKK cascade; positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of GTPase activity; positive regulation of JNK cascade; positive regulation of MAP kinase activity; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of protein amino acid phosphorylation; positive regulation of Ras protein signal transduction; positive regulation of tumor necrosis factor production; protein oligomerization; signal transduction
Research Articles on RASGRP1
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Product Notes
The RASGRP1 rasgrp1 (Catalog #AAA7048988) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RASGRP1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's RASGRP1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunofluorescence (IF). IF: 1: 50-1: 200. Researchers should empirically determine the suitability of the RASGRP1 rasgrp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RASGRP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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