Rabbit TRPA1 Polyclonal Antibody | anti-TRPA1 antibody

Rabbit Polyclonal to Human TRPA1

Cat. Num. AAA247915

• Gene Names: TRPA1; FEPS; ANKTM1
• Reactivity: Gibbon, Gorilla, Human
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: TRPA1; Polyclonal Antibody; Rabbit Polyclonal to Human TRPA1; Anti-TRPA1 Antibody (Internal) IHC-plus; ANKTM1; TRPA-1; Human TRPA1; anti-TRPA1 antibody

• Host: Rabbit
• Reactivity: Gibbon, Gorilla, Human
• Clonality: Polyclonal
• Specificity: Human TRPA1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 1119

• Applicable Applications for anti-TRPA1 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (7.5 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 19 amino acid peptide from internal region of human TRPA1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Marmoset, Bovine (89%); Monkey, Elephant, Dog, Rabbit, Pig (84%).
• Immunogen Type: Synthetic peptide
• Immunogen: TRPA1 antibody was raised against synthetic 19 amino acid peptide from internal region of human TRPA1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Marmoset, Bovine (89%); Monkey, Elephant, Dog, Rabbit, Pig (84%).
• Antigen Modification: Internal
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-TRPA1 antibody IHC of human ganglion cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-TRPA1 antibody

TRPA1 has been suggested to be a cold-activated ion channel. It has also been suggested to affect mechanotransduction and the perception of sound in vertebrates.

Product Categories/Family for anti-TRPA1 antibody

Family: Ion Channel; Subfamily: Calcium channel - TRP

NCBI and Uniprot Product Information

• NCBI GI #: 116534990
• NCBI GeneID: 8989
• NCBI Accession #: NP_015628.2
• NCBI GenBank Nucleotide #: NM_007332.2
• UniProt Accession #: O75762; A6NIN6
• Molecular Weight: 127,501 Da
• NCBI Official Full Name: transient receptor potential cation channel subfamily A member 1
• NCBI Official Synonym Full Names: transient receptor potential cation channel, subfamily A, member 1
• NCBI Official Symbol: TRPA1
• NCBI Official Synonym Symbols: FEPS; ANKTM1
• NCBI Protein Information: transient receptor potential cation channel subfamily A member 1; transformation-sensitive protein p120; ankyrin-like with transmembrane domains 1
• UniProt Protein Name: Transient receptor potential cation channel subfamily A member 1
• Protein Family: Transient receptor potential cation channel subfamily
• UniProt Gene Name: TRPA1
• UniProt Synonym Gene Names: ANKTM1
• UniProt Entry Name: TRPA1_HUMAN

NCBI Description

The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]

Uniprot Description

TRPA1: Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)- tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system. Belongs to the transient receptor (TC 1.A.4) family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 8q13

Cellular Component: stereocilium bundle; integral to plasma membrane; plasma membrane

Molecular Function: channel activity; calcium channel activity

Biological Process: response to drug; detection of chemical stimulus involved in sensory perception of pain; detection of mechanical stimulus involved in sensory perception of pain; response to hydrogen peroxide; ion transport; response to pain; response to cold; thermoception; transmembrane transport

Disease: Episodic Pain Syndrome, Familial, 1