Mouse GLIS family zinc finger 2 ELISA Kit | GLIS2 elisa kit
Mouse Zinc finger protein GLIS2, GLIS2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
GLIS2: Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway. Represses the Hedgehog-dependent expression of Wnt4. Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition. Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation. Defects in GLIS2 are the cause of nephronophthisis type 7 (NPHP7). NPHP7 is an autosomal recessive disorder resulting in end-stage renal disease during childhood or adolescence. It is a progressive tubulo-interstitial kidney disorder histologically characterized by modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts. Belongs to the GLI C2H2-type zinc-finger protein family.
Protein type: C2H2-type zinc finger protein
Cellular Component: transcription factor complex; cytoplasm; nuclear speck; nucleus
Molecular Function: protein binding; nucleic acid binding; DNA binding; metal ion binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; nervous system development; transcription, DNA-dependent; multicellular organismal development; positive regulation of transcription, DNA-dependent; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; negative regulation of smoothened signaling pathway; positive regulation of transcription from RNA polymerase II promoter; cell differentiation; negative regulation of transcription, DNA-dependent
Research Articles on GLIS2
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Product Notes
The Mouse GLIS2 glis2 (Catalog #AAA9331322) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9331322 ELISA Kit recognizes Mouse GLIS2. It is sometimes possible for the material contained within the vial of "GLIS family zinc finger 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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