Human ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 ELISA Kit | ATP6V0E1 elisa kit

Human V-type proton ATPase subunit e 1, ATP6V0E1 ELISA Kit

Cat. Num. AAA9331070

• Gene Names: ATP6V0E1; M9.2; ATP6H; Vma21; Vma21p; ATP6V0E
• Reactivity: Human
• Synonyms: ATPase; H+ transporting; lysosomal 9kDa; V0 subunit e1; Human V-type proton ATPase subunit e 1; ATP6V0E1 ELISA Kit; Human V-type proton ATPase subunit e 1 (ATP6V0E1) ELISA kit; ATP6H; ATP6V0E; M9.2; Vma21; Vma21p; H (+) -transporting two-sector ATPase; subunit H; V-ATPase 9.2 kDa membrane accessory protein; V-ATPase H subunit; V-ATPase M9.2 subunit; vacuolar ATP synthase subunit; ATP6V0E1 elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 4502319
• NCBI GeneID: 8992
• NCBI Accession #: NP_003936.1
• NCBI GenBank Nucleotide #: NM_003945.3
• UniProt Accession #: O15342; Q6IBE8; B2R557; D3DQM1
• Molecular Weight: 9,374 Da
• NCBI Official Full Name: V-type proton ATPase subunit e 1
• NCBI Official Synonym Full Names: ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
• NCBI Official Symbol: ATP6V0E1
• NCBI Official Synonym Symbols: M9.2; ATP6H; Vma21; Vma21p; ATP6V0E
• NCBI Protein Information: V-type proton ATPase subunit e 1; V-ATPase H subunit; V-ATPase subunit e 1; V-ATPase M9.2 subunit; vacuolar proton pump H subunit; vacuolar ATP synthase subunit H; vacuolar proton pump subunit e 1; vacuolar proton-ATPase subunit M9.2; V-ATPase 9.2 kDa membrane accessory protein; H(+)-transporting two-sector ATPase, subunit H
• UniProt Protein Name: V-type proton ATPase subunit e 1
• Protein Family: V-type proton ATPase
• UniProt Gene Name: ATP6V0E1
• UniProt Synonym Gene Names: ATP6H; ATP6V0E; V-ATPase subunit e 1
• UniProt Entry Name: VA0E1_HUMAN

NCBI Description

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is possibly part of the V0 subunit. Since two nontranscribed pseudogenes have been found in dog, it is possible that the localization to chromosome 2 for this gene by radiation hybrid mapping is representing a pseudogene. Genomic mapping puts the chromosomal location on 5q35.3. [provided by RefSeq, Jul 2008]

Uniprot Description

ATP6V0E1: Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the V-ATPase e1/e2 subunit family.

Protein type: Membrane protein, multi-pass; Transporter; Hydrolase; Transporter, iron; Transporter, ion channel; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q35.1

Cellular Component: phagocytic vesicle membrane; membrane; integral to membrane; endosome membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of ions; transporter activity; hydrogen ion transporting ATPase activity, rotational mechanism

Biological Process: interaction with host; vacuolar acidification; proton transport; cellular iron ion homeostasis; metabolic process; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; cell growth; response to amino acid stimulus; transmembrane transport