Rat seven in absentia homolog 2 (Drosophila) ELISA Kit | SIAH2 elisa kit
Rat E3 ubiquitin-protein ligase SIAH2, SIAH2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
a synaptophysin binding protein and also interact with E2 ubiquitin-conjugating enzyme UbcH8; involved in the regulating the ubiquitination and degradation of synaptophysin [RGD, Feb 2006]
Uniprot Description
Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. Promotes monoubiquitination of SNCA Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 can not.1 PublicationManual assertion based on experiment in:Ref.2
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Product Notes
The Rat SIAH2 siah2 (Catalog #AAA9330091) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9330091 ELISA Kit recognizes Rat SIAH2. It is sometimes possible for the material contained within the vial of "seven in absentia homolog 2 (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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