Rabbit anti-Human CB086 Polyclonal Antibody | anti-CB086 antibody

CB086, CT (WDPCP, BBS15, C2orf86, FRITZ, WD repeat-containing and planar cell polarity effector protein fritz homolog, Bardet-Biedl syndrome 15 protein, WD repeat-containing and planar cell polarity effector protein) (Azide free) (HRP)

Cat. Num. AAA6281061

• Gene Names: WDPCP; FRTZ; BBS15; FRITZ; C2orf86
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: CB086; Polyclonal Antibody; CT (WDPCP; BBS15; C2orf86; FRITZ; WD repeat-containing and planar cell polarity effector protein fritz homolog; Bardet-Biedl syndrome 15 protein; WD repeat-containing and planar cell polarity effector protein) (Azide free) (HRP); WDPCP; WD repeat-containing and planar cell polarity effector protein; anti-CB086 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-CB086 antibody: Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
• Application Notes: IHC: 1:50-100; ELISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: CB086 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 679-709 amino acids from the C-terminal region of human CB086.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(CB086 Antibody (C-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the CB086 antibody detected the CB086 protein (arrow).)

Immunohistochemistry (IHC)

(CB086 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CB086 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-CB086 antibody

The C2ORF86 gene encodes an ortholog of Drosophila 'fritz,' a cytoplasmic WD40 repeat protein that controls planar cell polarity (summarized by Kim et al., 2010 [PubMed 20671153]).

Product Categories/Family for anti-CB086 antibody

Antibodies; WD Repeat Proteins

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Kim, S.K., et al. Science 329(5997):1337-1340(2010). Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). Eeles, R.A., et al. Nat. Genet. 41(10):1116-1121(2009). Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008).

NCBI and Uniprot Product Information

• NCBI GI #: 111548652
• NCBI GeneID: 51057
• NCBI Accession #: NP_056994.3
• NCBI GenBank Nucleotide #: NM_015910.5
• UniProt Accession #: O95876; Q53RW4; Q7Z2Z3
• Molecular Weight: 66,655 Da
• NCBI Official Full Name: WD repeat-containing and planar cell polarity effector protein fritz homolog isoform 2
• NCBI Official Synonym Full Names: WD repeat containing planar cell polarity effector
• NCBI Official Symbol: WDPCP
• NCBI Official Synonym Symbols: FRTZ; BBS15; FRITZ; C2orf86
• NCBI Protein Information: WD repeat-containing and planar cell polarity effector protein fritz homolog; Bardet-Biedl syndrome 15 protein; WD repeat-containing protein C2orf86
• UniProt Protein Name: WD repeat-containing and planar cell polarity effector protein fritz homolog
• UniProt Gene Name: WDPCP
• UniProt Synonym Gene Names: BBS15; C2orf86; FRITZ; hFRTZ

Uniprot Description

Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies ().